. 2022 Oct 15;46(1):280–288. doi: 10.1038/s41440-022-01042-8

Table 2.

Prescribed antihypertensive drug classes and medication burden for SPYRAL HTN ON-MED patients prescribed ≥ 3 antihypertensive drugs at 36 months

	RDN ± SD (n = 23)	control ± SD (n = 23)	ANCOVA difference (95% CI)	p value
Number of AH medications at 36 months	3.7 ± 0.7	3.9 ± 1.2	−0.2 (−0.8,0.4)	0.49
AH medication burden at 36 months	10.5 ± 5.6	15.9 ± 18.6	−5.2 (−13.3,2.8)	0.20

Antihypertensive medication burden is a composite index based on the doses of medications but multiplies this result by the number of prescribed medications. Antihypertension medication burden is calculated for all antihypertensive medication prescribed at study specified follow-up visits for each patient and added to yield a single, summative score. All classes of drug are considered equivalent in potency so the “class weight” is set a “1” for all antihypertensive medications

$M e d I n d e x 2 = n o . o f m e d s \sum_{A H M e d s} (c l a s s w e i g h t \frac{p r e s c r i b e d d o s e}{s t a n d a r d d o s e})$

Class weight = 1

Standard dose = JNC 7 max daily recommended dose

SD standard deviation, CI confidence interval, AH antihypertensive