Subject	Biological sciences
Specific subject area	Cardiology and Cardiovascular Medicine Functional genetics Stem cell technology
Type of data	Figure Video Excel
How the data were acquired	Images and videos were recorded with the microscope. Expressional and genotyping data were acquired with qPCR and recorded in .xlsx format; analysed data were shown as graphs. Genomic locations were derived from the UCSC genome browser with the following link: https://genome.ucsc.edu.
Data format	Raw Analysed
Description of data collection	Human RNA and DNA samples for eQTL analyses were from patients undergoing cardiac surgeries collected in a previous project [1]. Human embryonic heart samples for in situ hybridisation were provided by the HDBR group. Functional experimental data were generated with in vitro human embryonic stem cell-cardiomyocytes differentiation model (hESC-CM) at D0, D2, D4, D6, D8, and D15. The control cells for experiments were transduced with CRISPR vector without targeting sgRNA sequences.
Data source location	Institution: Division of Cardiovascular Sciences, University of Manchester City: Manchester Country: UK
Data accessibility	Analysed data and figures are available in the article. Raw data of eQTL are available in “Raw data for STX18-AS1”, Mendeley Data, V1, doi: 10.17632/rpzs6fcdhz.1 Supplementary videos are in “Video supplements”, Mendeley Data, V1, doi: 10.17632/rw949cx3y8.1
Related research article	Yingjuan Liu, Mun-kit Choy, Sabu Abraham, Gennadiy Tenin, Graeme C. Black, Bernard D. Keavney. “Atrial Septal Defect (ASD) associated long noncoding RNA STX18-AS1 maintains time-course of in vitro cardiomyocyte differentiation” Genes and Diseases, DOI:10.1016/j.gendis.2022.07.010.