Figure 4.
Molecular characterization and quantification of proteomic signals for efficient islet cell differentiation in PANC-1 U6 vs SiP cells. (a) Immunoblotting profile of PARP1 expression along with key pancreatic progenitor markers in SFM and activin-A induced differentiation in PANC-1 cells. (b) Quantification for endocrine reprograming transcription factors and ratio of progenitor (E-cadherin) states vs endocrine β cell (N-Cadherin) states. Data represented as mean ± sem, p-value show significance at 95% confidence interval using two-way anova analysis compared to U6 cells (n = 3).
