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. 2022 Dec 13;12:21496. doi: 10.1038/s41598-022-25405-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Molecular characterization and quantification of proteomic signals for efficient islet cell differentiation in activin-A treated with and without PJ34 treatment in PANC-1 cells. (a) Immunoblotting profile at day 10th of differentiation of PARP-1 expression along with key pancreatic progenitor markers and activin-A induced endocrine pathway proteins that governs pancreatic islet formation from PANC-1 cells. (b) Quantification for endocrine reprograming transcription factor, ratio of progenitor (E-cadherin) state vs endocrine β cell (N-Cadherin) state, and MAPK signal (p-p38/p-38) stimulation. (c) Short-term (d1-6) protein profiling of differentiation signals initiated within activin-A treated cells with and without PJ34. Data represented as mean ± sem, p-value show significance at 95% confidence interval using two-way anova analysis compared to activin-A cells (n = 3).