Table 2.
C-index of the Cox proportional hazards (CPH) models vs optimal survival tree (OST) models using. Two feature sets are: FSI (7 features) and FSII (11 features). Models in bold perform the best in their corresponding cohorts. NSMP refers to no specific molecular profile subtype, MMRd – mismatch repair deficient, p53ab – p53 aberrant. 95% confidence intervals (CI95) are calculated using 1,000 iterations of the ordinary bootstrap with replacement.
| Feature Set | Model | Cohort | C-index | CI95 |
|---|---|---|---|---|
| I | CPH | All | 0.8425 | 0.0653 |
| II | 0.8489 | 0.0637 | ||
| I | OST | 0.8493 | 0.0564 | |
| II | 0.8586 | 0.0607 | ||
| I | CPH | NSMP | 0.8376 | 0.1727 |
| II | 0.8325 | 0.1772 | ||
| I | OST | 0.8368 | 0.1468 | |
| II | 0.8284 | 0.1542 | ||
| I | CPH | MMRd | 0.8200 | 0.0874 |
| II | 0.8251 | 0.0877 | ||
| I | OST | 0.7886 | 0.0865 | |
| II | 0.8843 | 0.0707 | ||
| I | CPH | p53ab | 0.7636 | 0.1508 |
| II | 0.7744 | 0.1541 | ||
| I | OST | 0.7246 | 0.1470 | |
| II | 0.7936 | 0.1245 |