Correction to: Scientific Reports 10.1038/s41598-022-22693-0, published online 01 November 2022
The original version of this Article contained errors in reference citations in the Discussion section.
IL-1 and TNF-α genes are transcriptionally activated in patients and in experimental models of APL44–48. IL-1 and TNF-α activate bone-resorbing giant cells that can increase bone loss around implants, which is characteristic of APL49. Osteoporotic fractures due to a reduction in the bone mineral density are associated with an 86-base pair repeat polymorphism in the IL-1RN gene50. There is a linkage disequilibrium between IL-1α, IL-1β and IL-1RN genes, all of which are encoded very close to each other on the long arm of chromosome 251. Thus, it is difficult to be sure whether these associations are specific for a particular gene in the IL-1 family, or even depend on other unknown gene from the same chromosome. Some haplotypes of the IL1R1-IL1A-IL1BIL1RN gene cluster associated with enhancement to (IL1A-IL1B-IL1RN haplotype) or protection against knee osteoarthritis (IL1B-IL1RN haplotype)20. Associations between polymorphisms in the IL-1 gene and aseptic loosening have been studied in maxillofacial surgery. An association between carriage of the IL-1β (+ 3954 C/T, exon 5) T allele and other IL-1 polymorphisms and unsuccessful retaining overdentures and periodontitis in smokers and non-smokers was reported21,52–56.
now reads:
IL-1 and TNF-α genes are transcriptionally activated in patients and in experimental models of APL44–47. IL-1 and TNF-α activate bone-resorbing giant cells that can increase bone loss around implants, which is characteristic of APL48. Osteoporotic fractures due to a reduction in the bone mineral density are associated with an 86-base pair repeat polymorphism in the IL-1RN gene49. There is a linkage disequilibrium between IL-1α, IL-1β and IL-1RN genes, all of which are encoded very close to each other on the long arm of chromosome 250. Thus, it is difficult to be sure whether these associations are specific for a particular gene in the IL-1 family, or even depend on other unknown gene from the same chromosome. Some haplotypes of the IL1R1-IL1A-IL1BIL1RN gene cluster associated with enhancement to (IL1A-IL1B-IL1RN haplotype) or protection against knee osteoarthritis (IL1B-IL1RN haplotype)20. Associations between polymorphisms in the IL-1 gene and aseptic loosening have been studied in maxillofacial surgery. An association between carriage of the IL-1β (+ 3954 C/T, exon 5) T allele and other IL-1 polymorphisms and unsuccessful retaining overdentures and periodontitis in smokers and non-smokers was reported21,51–56.
The original Article has been corrected.