Table 5.
Adverse events included in the literature.
| Adverse events | Control(n) | Intervention(n) |
|---|---|---|
| Rhinitis | Placebo 3 | ITSN 17 |
| Headache/Dizziness | Placebo 22 | ITSN 19 |
| RLZ 35 | ||
| Musculoskeletal Injury/Pain | Placebo 10 | ITSN 12 |
| RLZ 25 | ||
| Nose bleed/ Nasal irritation | Placebo 26 | ITSN 68 |
| Gastointestinal Symptoms/Diarrhea | Placebo 32 | ITSN 62 |
| Fall | Placebo 31 | ITSN 5 |
| RLZ 31 | ||
| Rash | Placebo 2 | ITSN 3 |
| Upper respiratory tract infection | Placebo 2 | ITSN 3 |
| Respiratory/sinus symptoms | Placebo 3 | ITSN 7 |
| Dental | Placebo 1 | ITSN 3 |
| Infection | Placebo 0 | ITSN 2 |
| Cardiovascular | Placebo 0 | ITSN 2 |
| Nausea | Placebo 4 | ITSN 5 |
| Cold symptoms | Placebo 14 | PLZ 14 |
| Glucose level low/asymptomatic | Placebo 4 | PLZ 4 |
| Swelling/edema of leg/ Peripheral edema | Placebo 11 | PLZ 7 |
| RLZ 106 | ||
| Anemia | Placebo 4 | PLZ 3 |
| RLZ 26 | ||
| Fatigue | Placebo 5 | PLZ 3 |
| Increased confusion | Placebo 5 | PLZ 3 |
| Insomnia | Placebo 2 | RLZ 5 |
| Other (stroke, breast cancer, weakness, ophthalmic, hypoglycemia, hematological, hearing loss, endocrine) | Placebo 18 | ITSN 70 |
MTN, Metformin; ITSN, Intranasal insulin; PLZ, Pioglitazone; RLZ, Rosiglitazone.