Table 3.
Putative CQAs for MSC(AT) angiogenic fitness.
| Marker/Characteristic | Licensed/Unlicensed | Gene/protein | Min/Max Function | Min value | Max value | p value | R2 value |
|---|---|---|---|---|---|---|---|
| SMAD7 | Licensed | Gene | Min | 194.72 | 504.28 | *0.0117 | 0.4237 |
| HGF | Licensed | Gene | Min | 139.8 | 4151.35 | *0.0187 | 0.3807 |
| ANG | Licensed | Gene | Min | 1 | 61.01 | *0.0285 | 0.3404 |
| VEGF | Licensed | Protein | Max | 15.2 | 942.15 | *0.0328 | 0.3048 |
| SOX9 | Unlicensed | Gene | Min | 1 | 61.46 | *0.0381 | 0.2906 |
| IDO1 | Licensed | Gene | Min | 4326.67 | 17824.17 | 0.0501 | 0.2832 |
| VEGF | Unlicensed | Protein | Max | 250.575 | 1463.65 | 0.0743 | 0.2416 |
| TSG101 | Licensed | Gene | Min | 272.06 | 488.06 | 0.0744 | 0.2413 |
| CXCL8 | Licensed | Gene | Min | 25008.42 | 51553.32 | 0.0879 | 0.2234 |
| TNFAIP6 | Unlicensed | Gene | Min | 1 | 45.68 | 0.0809 | 0.216 |
Summary of regression analyses between HUVEC PC1 composite scores and MSC(AT) genes, soluble factors, and morphological features. Marker/Characteristic column indicates the gene or protein symbol, or morphological feature. Licensed/Unlicensed column indicates whether the factor was measured under licensed or unlicensed conditions. Min/Max Function column indicates whether minimization or maximation of the MSC(AT) characteristic was desirable based on positive or negative correlations in the linear regression analysis. Min value and Max value columns indicate the range of values measured across each gene (units: mRNA count) and soluble factor (units: pg/mL). All significant (*p<0.05) and near-significant correlations (p<0.01) are displayed.