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. 2022 Nov 30;13:994288. doi: 10.3389/fendo.2022.994288

Table 4.

Post-operative status guided RAT through guidelines.

ATA guidelines 2019 ESMO guidelines NCCN Guidelines
Indications 2009 ATA guidelines 2015 ATA guidelines NS 2018 NCCN guidelines 2020 NCCN guidelines 2021 NCCN guidelines
Post-operative status guided NS NS NS Post-operative unstimulated Tg levels (+) Post-operative unstimulated Tg >5–10 ng/mla Post-operative unstimulated Tg >5–10 ng/mla
Dx-WBS (-) Dx-WBS (-), CT/MRI+
Dosage 100-200 mCi 30-150 mCi 50-100 mCi 50-200 mCi 50-100mCi
T3&N1: the effectiveness of RAT >150 mCi is uncertain RAI for known disease (100-200mCi) is embodied in RAT (50-100mCi).

ATg values obtained 6–12 weeks after total thyroidectomy; Additional cross-sectional imaging (CT or MRI of the neck with contrast and chest CT with contrast) should be considered to rule out the presence of significant normal thyroid remnant or gross residual disease and to detect clinically significant distant metastases).

NS, not stated.