Table 4.
ATA guidelines | 2019 ESMO guidelines | NCCN Guidelines | ||||
---|---|---|---|---|---|---|
Indications | 2009 ATA guidelines | 2015 ATA guidelines | NS | 2018 NCCN guidelines | 2020 NCCN guidelines | 2021 NCCN guidelines |
Post-operative status guided | NS | NS | NS | Post-operative unstimulated Tg levels (+) | Post-operative unstimulated Tg >5–10 ng/mla | Post-operative unstimulated Tg >5–10 ng/mla |
Dx-WBS (-) | Dx-WBS (-), CT/MRI+ | |||||
Dosage | 100-200 mCi | 30-150 mCi | 50-100 mCi | 50-200 mCi | 50-100mCi | |
T3&N1: the effectiveness of RAT >150 mCi is uncertain | RAI for known disease (100-200mCi) is embodied in RAT (50-100mCi). |
ATg values obtained 6–12 weeks after total thyroidectomy; Additional cross-sectional imaging (CT or MRI of the neck with contrast and chest CT with contrast) should be considered to rule out the presence of significant normal thyroid remnant or gross residual disease and to detect clinically significant distant metastases).
NS, not stated.