Table 3.

Multivariate Cox regression confirms independency of lymphocytic FoxP3 expression (A) as prognostic factor for OS when adjusting for age (B), but not with grading (C), pT (D) and FIGO-staging (E). Significant results are shown in bold

		p	Hazard Ratio (95%CI)
A	Covariate
	FoxP3 high vs. low	0.014**	1.574 (1.095–2.261)
B	Covariate
	FoxP3 high vs. low	0.018**	1.549 (1.078–2.226)
	Age at diagnosis	< 0.001***	1.081 (1.058–1.103)
C	Covariate
	FoxP3 high vs. low	0.221	1.271 (0.865–1.868)
	Age at diagnosis	< 0.001***	1.079 (1.057–1.101)
	Grading (Reference G1)	0.001***
	G1 vs. G2 G1 vs. G3	0.045  < 0.001	1.503 (1.009–2.238) 2.936 (1.635–5.272)
D	Covariate
	FoxP3 high vs. low	0.509	1.138 (0.775–1.673)
	Age at diagnosis	< 0.001***	1.084 (1.062–1.107)
	Grading (Reference G1)	0.001***
	G1 vs. G2 G1 vs. G3	0.294 0.000	1.249 (0.825–1.892) 3.102 (1.746–5.513)
	FIGO (Reference FIGO I)	< 0.001***
	I vs. II I vs. III/IV	0.280  < 0.001	1.473 (0.729–2.977) 2.904 (1.851–4.558)
E	Covariate
	FoxP3 high vs. low	0.632	1.308 (0.894–1.915)
	Age at diagnosis	< 0.001***	1.083 (1.060–1.106)
	Grading (Reference G1)	0.001***
	G1 vs. G2 G1 vs. G3	0.339 0.000	1.225 (0.808–1.855) 3.008 (1.699–5.326)
	pT (Reference pT1)	< 0.001***
	1 vs. 2 1 vs. 3/4	0.169  < 0.001	1.600 (0.819–3.127) 3.285 (2.042–5.286)