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. 2022 Dec 13;5:1367. doi: 10.1038/s42003-022-04075-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a In the “sponge” model of lncRNA gene expression regulation, lncRNA competitively inhibit miRNA which would otherwise be responsible for inhibiting mRNA. b Heatmap showing expression of 11 lncRNAs with miRNA-dependent associations to protein-coding genes in the four cancer driver pathways. The samples shown are a random subset with equal representation from each dataset in each disease. c Boxplots showing expression of the 11 lncRNA associated with four cancer driver pathways. All samples from both datasets are shown. (Two-sided Mann–Whitney significance test; *P value < 0.05, **P value < 0.01, ***P value < 0.001).