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. 2022 Dec 13;12:21561. doi: 10.1038/s41598-022-25783-1

Figure 3.

Figure 3

Altered rhythmic clock-genes expression in the retina upon GLAST+ cells-specific Bmal1 deletion. Altered daily rhythms expression of some clock genes, i.e., Bmal1, Cry1, Per1, and Dbp, in the retina of Bmal1cKO (red) compared to Ctrl (blue) in adult mice under 12:12 h LD cycles. The yellow background depicts the light phase (ZT 0–12), and the gray represents the dark phase (ZT 12–24). Samples were harvested at four equally distributed time points during the day, and ZT24 time points are the ZT0 ones shown again. Each curve depicts the best fitting (P < 0.05) between a cosine fitting with a period of 24 h or linear regression. Mean ± SEM of 4–6 animals per group at each time point, performed in triplicates (n = 4–6 per strain, Multiple t-tests, *P < 0.05, **P < 0.01, and ***P < 0.001 vs. Ctrl) are shown.