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. 2022 Dec 13;12:21561. doi: 10.1038/s41598-022-25783-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Bmal1 deletion affects ON RGCs maximum firing rate in response to light in mesopic conditions. (a) Averaged normalized PSTH (mean ± SEM) of all RGCs belonging to the most abundant ON clusters (both genotypes, all ZTs at CT100) #8, #5, #10, and #6 in response to full-field white-black alternating flashes (stimulus indicated above). (b) The proportion of recorded RGCs per ZTs (Top, Ctrl and bottom, Bmal1cKO). All cells from different experiments pulled together. (c) Analysis of the maximum firing rate in response to alternating bright and dark flashes performed on selected ON RGCs clusters (different rows) at four different ZTs (0, 6, 12, 18) and different contrasts (CTs, different columns). Data are shown as mean ± SEM between cells belonging to a specific cluster, separately for Ctrl (blue) and Bmal1cKO (red). Asterisks mark a significant difference between groups. (Kolmogorov–Smirnov test; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001). (d) Scatter plots of RGCs peak amplitudes normalized to the maximal response of the control throughout the day in Ctrl (y-axes) vs. Bmal1cKO (x-axes) conditions. Different colors indicate results obtained at diverse ZTs, and the symbols denote contrast conditions. Dashed line: unity line.