Table 4.

Data from the three models from the Varian Model Analytics program showing the optimisation objectives as well as minimum (min), mean, maximum (max) and standard deviation for the target and organs-at-risk both volumetrically and dosimetrically

	Model A	Model B	UCSD
Optimisation objectives
PTV			D10% < 102% Priority 100
	D0% < 104% Priority 150	D0% < 102.5% Priority 110	D0% < 103% Priority 150
	D100% > 98% Priority 140	D100% > 100% Priority 130	D100% > 97% Priority 150
			D98% > 100% Priority 150
		D95% < 100% Priority 0*
CTV or PTV inner		D0% < 106.5% Priority 140
		D15% < 105% Priority 90
	D100% > 101% Priority 160	D100% > 103% Priority 130
Bladder	V99% < 0% Priority 90	V103.5% < 0% Priority 120	V95% < GV Priority 80
			V50% < GV Priority 80
			V25% < GV Priority 30
	Line Priority 60	Line Priority 65	Line GP
Femur_L/Femur_R			Line GP
Femoral Heads	Line Priority 60
Penile Bulb			Line GP
Rectum	V99% < 0% Priority 90	V102% < 0% Priority 80	V100% < 0% Priority 150
			V95% < GV Priority 100
			V75% < GV Priority 90
			V50% < GV Priority 90
			V25% < GV Priority 80
			V10% < GV Priority 50
	Line Priority 60	Line GP	Line Priority 70
Input plan data
Number of Targets	2	3	1
Number of OARs	3	3	5
Total number of plans	93	41	105
Targets	CTV	PTV inner	PTV
	PTV_High	PTV optimise
		PTV low
OARS	Bladder	Bladder	Bladder
	Rectum	Rectum	Rectum
	Femoral Heads	Femoral Heads	Femur_L
			Femur_R
			Penilebulb
PTV Target	PTV_High	PTV optimise	PTV
Volumetric [cm3]
Min	70.39	7.44	44.55
Max	402.73	462.92	387.32
Mean	163.93	197.45	135.54
Std	70.46	82.42	53.33
Mean Dose [Gy]
Min	32.59	45.07	9.15
Max	79.59	80.77	83.71
Mean	67.25	76.83	55.37
Std	8.24	7.83	26.17
Mean Dose [%]
Min	99.32	101.89	101.08
Max	102.77	103.55	103.56
Mean	101.09	102.67	101.86
Std	0.67	0.44	0.47
Central Target	CTV	PTV inner
Volumetric [cm3]
Min	17.95	22.23
Max	146.62	191.43
Mean	54.59	69.47
Std	21.50	37.21
Mean Dose [Gy]
Min	32.87	45.76
Max	80.41	81.36
Mean	68.17	77.52
Std	8.40	8.11
Mean Dose [%]
Min	101.35	95.42
Max	104.28	104.31
Mean	102.46	102.98
Std	0.64	1.42
Bladder
Volumetric
Total min [cm3]	68.71	42.24	76.72
In-field min [cm3]	30.11	17.49	55.26
In-field min [%]	19.57	33.72	16.43
Out-of-field min [cm3]	0	0	0
Out-of-field min [%]	0	0	0
Overlap with target min [cm3]	1.84	2.61	2.9
Overlap with target min [%]	1.04	2.88	1.16
Total max [cm3]	632.26	546.2	685.52
In-field max [cm3]	261.84	358.76	555.6
In-field max [%]	87.25	94.93	94.15
Out-of-field max [cm3]	249.11	162.08	437.94
Out-of-field max [%]	52.2	45.37	66.49
Overlap with target max [cm3]	137.44	65.46	42.64
Overlap with target max [%]	60.63	66.28	22.7
Total mean [cm3]	236.83	192.06	265.39
In-field mean [cm3]	112.08	133.92	145.72
In-field mean [%]	53.23	71.2	60.75
Out-of-field mean [cm3]	41.2	26.95	50.41
Out-of-field mean [%]	11.77	10.5	13.25
Overlap with target mean [cm3]	24.4	20.56	13.04
Overlap with target mean [%]	12.04	13.8	5.67
Total std [cm3]	125.16	105.86	142.72
In-field std [cm3]	43.56	69.86	71.01
In-field std [%]	18.12	13.92	19.45
Out-of-field std [cm3]	64.59	40.20	88.80
Out-of-field std [%]	15.52	12.94	17.53
Overlap std [cm3]	22.47	12.17	8.95
Overlap std [%]	10.51	11.93	3.99
Mean Dose [Gy]
Min	7.12	16.25	1.59
Max	58.99	60.66	40.51
Mean	26.10	38.23	16.93
Std	13.05	11.58	10.85
Mean Dose [%]
Min	11.89	20.84	7.39
Max	89.38	81.97	55.77
Mean	38.92	50.99	29.83
Std	18.26	14.78	11.25
Rectum
Volumetric
Total min [cm3]	27.65	34.36	34.27
In-field min [cm3]	21.76	28.31	19.47
In-field min [%]	61.59	63.95	37.76
Out-of-field min [cm3]	0	0	0
Out-of-field min [%]	0	0	0
Overlap with target min [cm3]	0	0.22	0
Overlap with target min [%]	0	0.44	0
Total max [cm3]	111.58	145.84	226.16
In-field max [cm3]	101.4	108.79	134.92
In-field max [%]	97.79	94.83	98.35
Out-of-field max [cm3]	8.51	38.55	81.98
Out-of-field max [%]	18.67	26.44	46.33
Overlap with target max [cm3]	13.87	23.86	8.99
Overlap with target max [%]	22.25	29.98	12.61
Total mean [cm3]	56.19	69.68	74
In-field mean [cm3]	47.53	57.07	55.92
In-field mean [%]	84.82	83.41	78.22
Out-of-field mean [cm3]	0.36	4.24	6.28
Out-of-field mean [%]	0.57	4.73	6.47
Overlap with target mean [cm3]	4.85	6.5	2.76
Overlap with target mean [%]	8.6	9.46	3.97
Total std [cm3]	18.3	27.57	31.6
In-field std [cm3]	15.92	20.26	20.44
In-field std [%]	6.89	8.94	13.93
Out-of-field std [cm3]	1.39	8.37	13.58
Out-of-field std [%]	2.35	6.82	9.65
Overlap std [cm3]	3.24	4.3	1.75
Overlap std [%]	5.25	5.63	2.49
Mean Dose [Gy]
Min	18.59	18.75	3.7
Max	44	48.63	36.24
Mean	32.43	42.44	19.02
Std	6.73	5.58	10.06
Mean Dose [%]
Min	30.99	42.62	16.83
Max	66.01	70.2	48.58
Mean	48.64	56.2	34.27
Std	8.3	5.75	6.84
Femoral Heads/Femur			Left, Right
Volumetric
Total min [cm3]	50.41	113.12	46.38, 46.26
In-field min [cm3]	41.42	102.78	32.17, 31.71
In-field min [%]	57.38	59.55	48.84, 49.37
Out-of-field min [cm3]	0	0	0, 0
Out-of-field min [%]	0	0	0, 0
Overlap with target min [cm3]	0	0	0, 0
Overlap with target min [%]	0	0	0, 0
Total max [cm3]	120.6	291.3	269.29, 266.21
In-field max [cm3]	120.52	271.62	196.92, 211.32
In-field max [%]	100	100	100, 100
Out-of-field max [cm3]	15.76	47.5	73.47, 75.49
Out-of-field max [%]	16.47	26.21	27.28, 28.36
Overlap with target max [cm3]	0	0	0, 0
Overlap with target max [%]	0	0	0, 0
Total mean [cm3]	77.94	177.92	69.02, 69.85
In-field mean [cm3]	74.63	147.54	63.87, 64.8
In-field mean [%]	95.97	83.39	94.49, 94.63
Out-of-field mean [cm3]	0.51	8.57	2.29, 2.14
Out-of-field mean [%]	0.58	4.53	1.54, 1.41
Overlap with target mean [cm3]	0	0	0, 0
Overlap with target mean [%]	0	0	0, 0
Total std [cm3]	14.88	27.4	35.91, 35.1
In-field std [cm3]	15.05	23.08	26.65, 26.06
In-field std [%]	8.56	8.47	10.53, 10.54
Out-of-field std [cm3]	1.95	10.69	10.79, 10.74
Out-of-field std [%]	2.25	5.37	5.29, 5.05
Overlap std [cm3]	0	0	0, 0
Overlap std [%]	0	0	0, 0
Mean Dose [Gy]
Min	4.85	5.18	1.32, 1.17
Max	32.57	29.25	27.99, 24.05
Mean	17.58	17.17	12.03, 11.95
Std	6.17	4.61	7.36, 7.27
Mean Dose [%]
Min	7.39	6.64	5.21, 3.28
Max	49.34	38.53	35.74, 32.85
Mean	26.37	23.19	21.88, 21.75
Std	8.54	6.52	6.99, 6.94

G generated, D dose, V volume, P priority

^aObjective affects normal tissue objective