Table 2.
Alpha Diversity Measures and BMI at Baseline and Changes Over Time by Chemotherapy Treatment and by BMI
| By Chemotherapy | By Body Mass Index (BMI) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Neoadjuvant (neoADJ) N = 16 | Adjuvant (ADJ) N = 13 | No Chemotherapy (noC) n = 4 | P(1df)a neoADJ vs. ADJ+noC | P (1df) b neoADJ vs. ADJ | Proc Mixed P valued | BMI Loss n = 16 |
BMI gain N = 17 | P (1df) | Proc Mixed P valuee | ||
| Observed species (OTU) | Baseline | 32.00 (7.49) | 34.15 (7.78) | 35.50 (14.48) | 0.47 | 0.43 | 34.31 (2.19). | 32.29 (1.98) | 0.79 | ||
| Change | 5.25 (8.43) | 0.53 (11.27) | −4.00 (2.58) | 0.07 | 0.24 | 5.88 (2.18) | −1.12 (2.27) | 0.06 | |||
| P c | 0.03 | 0.85 | 0.13 | 0.28 | 0.02 | 0.72 | 0.03 | ||||
| Chao1 | Baseline | 57.03 (18.56) | 70.01 (25.80) | 68.35 (42.18) | 0.19 | 0.11 | 67.46 (6.92) | 59.80 (5.37). | 0.52 | ||
| Change | 29.44 (51.77) | −5.64 (27.79) | −3.03 (7.12) | 0.04 | 0.05 | 27.36 (13.13) | −3.08 (6.20) | 0.04 | |||
| P c | 0.03 | 0.50 | 0.63 | 0.05 | 0.03 | 0.64 | 0.04 | ||||
| Shannon | Baseline | 2.87 (0.39) | 2.90 (0.41) | 3.10 (0.49) | 0.59 | 0.63 | 2.99 (0.09) | 2.84 (0.10) | 0.56 | ||
| Change | 0.20 (0.34) | 0.07 (0.61) | −0.18 (0.13) | 0.10 | 0.31 | 0.2 (0.1) | 0.01 (0.12) | 0.33 | |||
| P c | 0.02 | 0.84 | 0.13 | 0.56 | 0.06 | 0.89 | 0.25 | ||||
| PD whole tree | Baseline | 11.23 (2.22) | 11.65 (2.32) | 10.37 (2.84) | 0.94 | 0.69 | 11.42 (0.54) | 11.17 (0.6) | 0.86 | ||
| Change | 1.25 (2.65) | 0.28 (2.90) | 0.82 (2.45) | 0.30 | 0.29 | 1.76 (0.68) | −0.08 (0.58) | 0.08 | |||
| P c | 0.09 | 0.95 | 0.88 | 0.46 | 0.04 | 0.85 | 0.05 | ||||
| Body mass index | Baseline | 31.05 (5.56) | 30.21 (8.30) | 36.11 (14.52) | 0.49 | 0.36 | 31.47 (2.29) | 31.21 (1.69) | 0.77 | ||
| (kg/m2) | Change | −0.71 (3.03) | 0.29 (1.70) | 0.07 (1.22) | 0.61 | 0.51 | −2.03 (0.55) | 1.49 (0.19) | <0.0001 | ||
| P c | 0.74 | 0.47 | 0.88 | 0.37 | <0.0001 | <0.0001 | <0.0001 | ||||
Notes: aP value obtained by Wilcoxon rank sum test, comparing neoADJ group (n = 16) vs. combined group of ADJ + noC (n = 17). bP value obtained by Wilcoxon rank sum test, comparing neoADJ group vs. ADJ group. cWilcoxon signed rank test (1df) comparing change (baseline to end collection) in alpha diversity measures. dP value from proc mixed effects regression which also adjusted for weight changes. eP value from proc mixed effects regression which also adjusted for chemotherapy treatment.