. 2022 Dec 9;14:433–451. doi: 10.2147/BCTT.S305486

Table 4.

Mean Baseline (B) and Absolute Changes (Δ) in Alpha Diversity Measures and Relative Abundance Levels of Select Taxa by Specific Chemotherapy Agents

Alpha diversity		AC		Taxol		TCHP		Herceptin
		No	Yes	No	Yes	No	Yes	No	Yes
		N = 18	N = 15	N = 19	N = 14	N = 25	N = 8	N = 22	N = 11
Observed species	B	32.4	34.3	32.9	33.8	34.7	29.9^a	34.9	30.0
	Change	3.3	1.1	4.1 ^b	−0.21	0.08	9.13 ^b	1.64	3.55
	P^c		0.34		0.22		0.009		0.065
Chao1	B	60.4	67.2	60.9	67.1	69.2	48.9 ^a	68.7	53.1
	Change	14.4	8.4	24.6 ^b	−5.9	6.4	28.9 ^b	10.8	13.4
	P^c		0.13		0.026		0.02		0.52
Shannon	B	2.90	2.93	2.91	2.92	2.97	2.72 ^a	2.99	2.76
	Change	0.14	0.05	0.18	0.00	0.00	0.42 ^b	0.06	0.18
	P^c		0.37		0.31		0.02		0.22
PD whole tree	B	11.0	11.7	11.2	11.5	11.5	10.6	11.6	10.78
	Change	0.95	0.65	1.13	0.39	0.34	2.3 ^b	0.70	1.05
	P^c		0.77		0.44		0.05		0.62
Select taxa
p__Actinobacteria	B	0.04	0.21	0.04	0.24 ^a	0.15	0.03	0.07	0.23
f__ Actinomycetaceae	Change	0.01	−0.18	0.02	−0.20	−0.09	−0.01	−0.01	−0.21
g__Actinomyces	P^c		0.03		<0.01		0.64		0.25
p__Actinobacteria	B	0.01	0.02	0.003	0.025 ^a	0.02	0.00	0.01	0.02
f__ Micrococcaceae	Change	0.00	−0.01	0.01	−0.020 ^b	−0.01	0.00	0.00	−0.02
g_ Rothia	P^c		0.07		<0.01		0.65		0.04
p__Bacteroidetes	B	0.03	0.02	0.03	0.02	0.02	0.06	0.02	0.05
f_ Rikenellaceae	Change	−0.02	0.00	−0.02	0.00	0.00	−0.05	0.00	−0.04
g_ Alistipes	P^c		0.39		0.19		0.04		0.03
p_ Firmicutes	B	0.12	1.81	0.12	1.92	1.11	0.17	1.25	0.15
f_ Lactobacillaceae	Change	0.89	−1.55	0.99	−1.85	−0.67	1.19	−0.75	0.84
g_ Lactobacillus	P^c		0.12		0.02		0.80		0.58
p__Firmicutes	B	2.38	4.43 ^a	1.48	5.80 ^a	3.84	1.67	3.13	3.69
f __Streptococcaceae	Change	−0.05	−1.00	1.16	−2.70	−0.20	−1.36	0.71	−2.86
g.__Streptocooccus	P^c		0.13		0.02		0.77		0.28
p__Firmicutes	B	1.34	0.95	1.28	1.01	1.49	0.13 ^a	1.62	0.24
f__ Clostridiaceae	Change	−0.35	−0.29	−0.23	−0.45	−0.66	0.73 ^b	−0.71	0.45
g__SMB53	P^c		0.45		0.17		0.01		0.19
p__Firmicutes	B	1.58	4.23 ^a	2.06	3.76	3.28	1.23	3.29	1.78
f__Lachnospiraceae	Change	1.74 ^b	−1.26	0.80	−0.20	−0.11	1.90 ^b	−0.30	1.72
g__Coprococcus	P^c		0.01		0.20		0.09		0.16
p__Firmicutes	B	2.11	3.10	2.21	3.03	3.11	0.82 ^a	3.05	1.58 ^a
f_ Lachnospiraceae	Change	0.54	−1.82 ^b	0.02	−1.28	−0.78	0.23	−0.75	−0.10
g_ Ruminococcus	P^c		0.02		0.33		0.33		0.38
p__Firmicutes	B	0.78	0.03	0.74	0.03	0.11	1.47	0.12	1.07
f__ Veillonellaceae	Change	−0.57	0.81 ^b	−0.43	0.71 ^b	0.53 ^b	−1.42	0.43 ^b	−0.68
g__Acidaminococcus	P^c		0.03		0.10		<0.01		0.02
p__Verrucomicrobia	B	0.12	0.93	0.12	0.99	0.65	0.03	0.71	0.04
f_ Verrucomicrobiaceae	Change	0.13	−0.46	0.12	−0.49	−0.34	0.49 ^b	−0.37	0.33
g__Akkermansia	P^c		0.29		0.48		<0.01		0.03

Notes: ^aWilcoxon rank sum test (1df) P < 0.05 when comparing user vs. nonuser of a specific chemotherapy agent. ^bP < 0.05 when comparing change, i.e., last collection- baseline level of a specific chemotherapy agent for user or nonuser. ^cP < 0.05 showing differences in the changes between last and baseline samples between user and nonuser of a specific chemotherapy agent.