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. 2022 Dec 13;12:21534. doi: 10.1038/s41598-022-25323-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Distribution of mutation frequencies per GPCR structural domain. (a) Mutation ratio found in each structural domain in the GDC dataset for GPCRs in all classes combined and independently. (b) Mutation ratio found in each structural domain in the 1000 Genomes dataset for GPCRs in all classes combined and independently. (c) Mutation ratio enrichment in the GDC dataset over the 1000 Genomes dataset. (d) Mutation ratio normalized over average domain length found in each structural domain in the GDC dataset for GPCRs in all classes combined and independently. (e) Mutation ratio normalized over average domain length found in each structural domain in the 1000 Genomes dataset for GPCRs in all classes combined and independently. (f) Length-normalized mutation ratio enrichment in the GDC dataset over the 1000 Genomes dataset. “TM”, “ICL” and “ECL” represent the (normalized) mutation ratios in aggregated domains. In panels (d–f), “Average” represents the average ratio considering a domain as the whole protein. In panels (a) and (d), a darker shade of red represents a higher (normalized) mutation ratio in the GDC dataset. In panels (b) and (e), a darker shade of blue represents a higher (normalized) mutation ratio in the 1000 Genomes dataset. In panels (c) and (f), a darker shade of red represents a higher (normalized) mutation ratio enrichment towards the GDC dataset, while a darker shade of blue represents a higher (normalized) mutation ratio enrichment towards the 1000 Genomes dataset.