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. 2022 Dec 13;12:21534. doi: 10.1038/s41598-022-25323-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Most frequently mutated residues in GDC corrected for natural variance. The 10 positions with the highest mutation frequency in GPCRs in the GDC dataset corrected for the mutation frequency in the 1000 Genomes dataset. (a) Analysis of all GPCR classes combined. (b) Analysis of Class A GPCRs. (c) Analysis of Class B GCPRs. (d) Analysis of Class C GPCRs. The residue location in Ballesteros-Weinstein notation is shown on the x-axis, while on the y-axis the corrected mutation frequency of that residue is given. “Average” is the average mutation frequency per residue over all the data.