Figure 5.

Crowding distances of the first and second Pareto fronts. (a) First Pareto front, consisting of 24 GPCRs. (b) Second Pareto front, consisting of 28 GPCRs. On the x-axis the gene names of GPCRs are shown, while on the y-axis their crowding distance is shown. Crowding distance was cut-off at 10, as the differences between these high-scoring receptors become negligible above that threshold. In grey, GPCRs detected by Pareto ranking using exclusively four mutation-derived objectives (light gray for the 1st front and darker grey for the 2nd front). In green, additional GPCRs that show up in the first two Pareto fronts by adding practical objectives to the recommendation system.