Table 1.
Characteristics of female and male offspring of DHT-treated dams compared to their age- and sex-matched controls.
| Adult male offspring(4-6 months of age) | Adult female offspring(4-6 months of age) | Post-estrous cycling female offspring(16-20 months of age) | ||
|---|---|---|---|---|
| Born smaller than controls (intra-uterine growth restriction) | Yes (47, 48) | Yes (46, 47) | ||
| Body weight | Lower (48) | Similar (46) | Similar (46) | |
| Lean mass | Lower (48) | Similar (46) | Similar (46) | |
| Fat mass | Similar (48) | Similar (46) | Similar (46) | |
| Serum total cholesterol | Higher (48) | Similar (46) | Higher (46) | |
| Proteinuria (marker of renal injury) | Higher (48) | Similar (46) | Higher (46) | |
| Urinary nitrates/nitrites (measure of the endogenous vasodilator NO) | Similar (48) | Lower (46) | Similar (46) | |
| Baseline blood pressure | Similar (48) | Similar (46) | Similar (46) | |
| Pressor response to Ang II after blocking endogenous RAS | Exaggerated (48) | Suppressed (46) | Suppressed (46) | |
| Pressor response to Ang II plus salt diet after blocking endogenous RAS | Not tested | Not tested | Suppressed (46) | |
NO, nitric oxide; Ang, angiotensin; RAS, renin-angiotensin system.