TABLE 4.

Independent lead variants that were confirmed between severe COVID-19 patients and general population.

SNP	Position	Allele (major/minor)	MAF (case/control)	p	OR (95%CI)	Mapped gene	Previous study	Previous study phenotype
rs1291122587	9:133270497	GA/G	0.26/0.59	7.02E-18	0.24 (0.18–0.34)	Intron of ABO	HGI	Hospitalized covid vs. population
								Hospitalized covid vs. population, leave out 23 and Me (EUR)
								Covid vs. population
								Covid vs. population, leave out 23 and Me (EUR)
rs8111981	19:977763	G/A	0.28/0.35	3.37E-02	0.70 (0.50–0.97)	Downstream of ARID3A	HGI	Very severe respiratory confirmed covid vs. population
rs9975538	21:33254549	C/T	0.29/0.37	4.37E-02	0.71 (0.52–0.98)	Intron of IFNAR2	HGI	Very severe respiratory confirmed covid vs. population
								Hospitalized covid vs. population
								Hospitalized covid vs. population, leave out 23 and Me (EUR)
rs429358	19:44908684	T/C	0.11/0	4.29E-14	NA	Missense of APOE	PMID: 32451547	Positive COVID-19 patients vs. participants negative or not tested
rs10734222	11:14244913	G/A	0.17/0.24	1.19E-02	0.61 (0.42–0.90)	Intron of SPON1	HGI	Hospitalized covid vs. population, leave out 23 and Me (EUR)
rs59492037	6:4571951	A/G	0.27/0.35	2.63E-02	0.68 (0.49–0.95)	Intron of AL162718.1	HGI	Very severe respiratory confirmed covid vs. not hospitalized covid
rs4302292	21:33919239	G/A	0.31/0.23	3.07E-02	1.47 (1.05–2.05)	Upstream of ATP5PO	HGI	Covid vs. population
rs71327056	3:46348485	C/G	0.01/0.04	3.12E-02	0.27 (0.08–0.92)	Intergenic of UQCRC2P1-CCR2	HGI	Very severe respiratory confirmed covid vs. population
								Hospitalized covid vs. population
								Hospitalized covid vs. population, leave out 23 and Me (EUR)
rs1886814	6:41534945	A/C	0.45/0.37	3.60E-02	1.39 (1.03–1.88)	Intron of FOXP4-AS1	HGI	Hospitalized covid vs. population