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. 2022 Dec 13;13:7709. doi: 10.1038/s41467-022-35314-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a A single neuron example showing the trial-averaged Vm during 8 Hz CoChR activation and 40 Hz DBS. The Vm has been smoothed with a 30 ms rectangular window to better highlight the depolarization effect in response to 8 Hz CoChR activation. This neuron exhibited prominent optogenetics-evoked Vm depolarization without DBS, and reduced Vm depolarization during 40 Hz DBS. Average SomArchon fluorescence of the example neuron is shown in the left image. Scale bar, 15 µm (b) Same as (a), but another neuron example with strong Vm depolarization during 40 Hz DBS. c The reduction of optogenetically induced 8 Hz Vm power is shown as a function of Vm change (DBS – Baseline) during 40 Hz (blue dots) and 140 Hz (red dots) DBS. Vm change is normalized by the average spike amplitude for each recorded neuron. Each dot represents a neuron (n = 41 neurons total). Neurons with stronger DBS-evoked Vm depolarization exhibit greater suppression of the 8 Hz optogenetically induced Vm power. The black line represents the fitted linear regression line. d The reduction of optogenetically induced 8 Hz spike-Vm phase locking value (PLV) is shown as a function of Vm depolarization amplitude during 40 Hz (blue dots) and 140 Hz (red dots) DBS (n = 28 total neurons). Neurons with less than 5 spikes during stimulation and baseline were excluded from this analysis. Source data are provided as a Source Data file.