TABLE 2.
Accuracy and precision of curcumol in rat plasma and tissue homogenates (n = 5).
Sample | Spiked concentration (ng/mL) | Intra-day | Inter-day | ||
---|---|---|---|---|---|
Accuracy | Precision | Accuracy | Precision | ||
% | (RSD, %) | % | (RSD, %) | ||
Plasma | 10 | 105.9 | 8.2 | 100.6 | 7.5 |
30 | 102.2 | 8.4 | 96.5 | 8.2 | |
400 | 110.9 | 2.0 | 98.3 | 9.8 | |
1,600 | 111.0 | 2.3 | 97.3 | 10.7 | |
Brain | 5 | 100.0 | 12.3 | 94.0 | 8.8 |
15 | 98.0 | 2.1 | 95.7 | 4.5 | |
160 | 97.3 | 1.7 | 98.3 | 1.7 | |
1,600 | 93.6 | 4.4 | 92.5 | 2.9 | |
Heart | 5 | 92.4 | 2.5 | 93.8 | 2.8 |
15 | 90.9 | 3.4 | 93.2 | 3.1 | |
160 | 88.0 | 2.2 | 99.3 | 8.5 | |
1,600 | 97.1 | 4.5 | 94.0 | 4.1 | |
Liver | 5 | 96.4 | 5.9 | 102.4 | 6.9 |
15 | 99.1 | 8.6 | 104.4 | 6.9 | |
160 | 98.6 | 3.4 | 106.3 | 5.9 | |
1,600 | 100.3 | 3.1 | 98.4 | 5.6 | |
Spleen | 5 | 94.6 | 6.7 | 97.6 | 8.1 |
15 | 104.1 | 7.5 | 102.4 | 6.6 | |
160 | 108.5 | 1.1 | 100.4 | 6.3 | |
1,600 | 101.5 | 5.6 | 96.6 | 6.1 | |
Lung | 5 | 96.4 | 7.6 | 97.3 | 7.5 |
15 | 102 | 4.4 | 96.4 | 5.8 | |
160 | 107.1 | 1.7 | 99.3 | 8.4 | |
1,600 | 89.1 | 0.9 | 93.4 | 7.3 | |
Kidney | 5 | 94.9 | 7.3 | 97.3 | 8.0 |
15 | 95.1 | 6.7 | 99.0 | 6.5 | |
160 | 94.9 | 4.7 | 101.2 | 8.4 | |
1,600 | 89.8 | 2.9 | 96.3 | 9.6 | |
Intestine | 10 | 100.6 | 8.6 | 102.0 | 7.4 |
30 | 100.7 | 6.0 | 102.9 | 4.7 | |
400 | 111.0 | 2.5 | 108.4 | 4.9 | |
4,000 | 94.1 | 3.4 | 95.9 | 3.9 | |
Colon | 10 | 109.4 | 3.5 | 102.1 | 8.0 |
30 | 103.1 | 6.6 | 105.0 | 5.3 | |
400 | 99.0 | 1.2 | 106.5 | 5.5 | |
4,000 | 90.9 | 3.6 | 96.6 | 5.9 |