TABLE 4.

Stability of curcumol in rat plasma and tissue homogenates (n = 5).

Sample	Spiked concentration (ng/mL)	12 h short-term		Auto-sampler (12 h,-4°)		Three freeze-thaw cycles		Long-term (30days,-80°)
		Accuracy	Precision	Accuracy	Precision	Accuracy	Precision	Accuracy	Precision
		%	(RSD, %)	%	(RSD, %)	%	(RSD, %)	%	(RSD, %)
Plasma	30	104.4	5.1	102.3	9.6	105.2	4.1	108.8	3.1
	400	105.5	4.8	110.3	1.6	110.3	3.3	96.0	8.0
	1,600	91.9	1.3	105.6	3.7	112	1.7	97.9	9.6
Brain	15	109.3	4.2	97.2	3.0	98.0	5.7	107.6	1.9
	160	105.3	8.0	101.9	1.8	109.6	2.3	94.9	4.0
	1,600	94.4	2.1	88.0	2.9	86.0	0.7	92.1	4.2
Heart	15	107.1	5.4	103.6	4.9	105.7	2.7	103.5	6.7
	160	109.4	1.5	102.5	8.0	99.3	7.5	108.8	1.8
	1,600	90.6	1.5	90.4	4.3	92.0	5.1	112.9	0.6
Liver	15	108.1	3.8	104.5	8.6	102.5	3.4	96.5	8.5
	160	109	5.1	110.6	2.4	111.1	1.8	109	2.6
	1,600	89.6	1.6	98.1	1.4	108.6	2.5	94.3	3.5
Spleen	15	102.8	9.1	105.1	10.5	105.9	5.6	102.4	6.7
	160	110.5	1.5	109.3	1.2	108.8	1.9	109.6	2.2
	1,600	89.3	1.0	98.6	1.4	97.9	2.1	100.5	0.3
Lung	15	106.8	8.2	107.5	6.4	106.0	6.6	108.8	1.7
	160	111.9	2.4	108.5	4.9	104.0	7.3	101.6	7
	1,600	92.3	7.4	93.9	4.9	96.8	2.6	102.4	2.4
Kidney	15	109.1	1.7	98.7	8.6	100.7	4.9	99.9	2.2
	160	109.5	0.6	107.6	8	97.3	8.1	103.6	0.9
	1,600	87.9	0.6	102.6	5.7	104.6	4.8	94.9	6.5
Intestine	30	108.7	4.8	99.8	3.5	103.8	6.5	94.0	6.7
	400	107.7	2.9	94.2	2.1	89.5	2.8	105.3	2.1
	4,000	93.6	4.1	88.6	1.6	92.3	2.6	91.9	2.1
Colon	30	109.5	1.3	97.2	6.5	100.5	6.2	104.8	4.4
	400	109.5	1.0	98.4	1.7	103.2	1.8	101.1	2.3
	4,000	89.9	3.7	92.8	5.2	89.5	1.0	102.3	6.8