TABLE 5.
The main pharmacokinetic parameters after oral administration of 10, 40 and 80 mg/kg curcumol; intravenous injection of 2.0 mg/kg curcumol (n = 5, mean ± SD).
| Parameters | i.v. (2.0 mg/kg) | i.g. Low dose (10 mg/kg) | i.g. mid dose (40 mg/kg) | i.g. high dose (80 mg/kg) |
|---|---|---|---|---|
| Tmax(h) | 0.08 ± 0.00 | 0.80 ± 0.27 | 0.30 ± 0.11 | 0.45 ± 0.11 |
| Cmax (ng/mL) | 233.80 ± 53.73 | 56.28 ± 8.35 | 126.36 ± 58.4 | 237.60 ± 87.97 |
| AUC0-t (μg/L*h) | 196.15 ± 40.15 | 128.87 ± 11.49 | 360.18 ± 34.08 | 746.09 ± 231.26 |
| AUC0-∞(μg/L*h) | 218.09 ± 42.97 | 181.76 ± 39.45 | 431.52 ± 20.6 | 837.18 ± 218.79 |
| MRT0-∞(h) | 1.68 ± 0.47 | 4.29 ± 1.92 | 4.41 ± 0.65 | 4.87 ± 1.18 |
| t1/2(h) | 1.25 ± 0.42 | 3.04 ± 1.86 | 3.86 ± 0.86 | 4.59 ± 1.66 |