Table 3.

Details on the various GO terms and the differentially regulated proteins corresponding to the particular GO terms.

Category	GO Term	Function	Differentially regulated genes in UMB treatment
Molecular Function	GO:0019843	rRNA binding	rpsS, rplD, rplE, rplC, rpsM, rplX, rpsH, rplB, era, rplW, rpsN, rplO, rlmN, rplP, rpsG, rpsQ, rplF, rplT, rplU, rpsL, rpsC, rpsE, rpsD, rplV
	GO:0003863	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity	bkdA1, bkdA2
	GO:0003729	mRNA binding	rplM, rpsG, rpsA, acnB, rpsC
	GO:0003735	Structural constituent of ribosome	rpmB,rpsA,rpsB, rplK, rplE, rplX, rpsH, rplJ, rplQ, rpsN, rpmC, rplP, rplN, rplY, rpsQ, rpsF, rplT, rpsC, rplV, rplS, rpsT, rpsI, rpsS, rplM, rpsK, rplD, rplC, rpsM, rplB, rplW, rplO, rpsG, rpsJ, rplF, rplU, rpsD, rpsL, rpsE, rplR
	GO:0000049	tRNA binding	metG, thrS, rplE, rpsM, rplP, rpsG, rlmN, rpsJ, rpsL, lysS, pheT, alaS
	GO:0000287	Magnesium ion binding	purA, bioD, sucC, eno, ribB, lysS, ppa, metK, dxs, ilvC, upp, purF, pheT
	GO:0004550	Nucleoside diphosphate kinase activity	sucD, sucC, ndk, adk
	GO:0070181	Small ribosomal subunit rRNA binding	rpsK, era, rpsT, rpsF
	GO:0003746	Translation elongation factor activity	tsf, fusA, fusB, efp
	GO:0008097	5S rRNA binding	rplY, rplR
	GO:0046933	Proton-transporting ATP synthase activity, rotational mechanism	atpG, atpF, atpA, atpH, atpC
	GO:0070180	Large ribosomal subunit rRNA binding	rplK, rplJ, rplN
	GO:0042802	Identical protein binding	aspC, azu, aruC, pyrG
	GO:0005525	GTP binding	folE2, purA, era, fusA, ftsZ, upp, fusB
	GO:0051082	Unfolded protein binding	groES, clpX, htpG, PA3647, grpE
	GO:0004775	Succinate-CoA ligase (ADP-forming) activity	sucD, sucC
	GO:0004148	Dihydrolipoyl dehydrogenase activity	lpdV, lpd, sthA
	GO:0003924	GTPase activity	era, fusA, ftsZ, fusB
	GO:0005524	ATP binding	clpB, gyrA, groES, atpG, gatB, bioD, xseA, atpA, adk, arcC, alaS, pyrG, metG, thrS, carA, metK, argS, htpG, pheT, sucC, glnA, proS, tyrS, atpC, lysS, clpX, ndk
Biological Processes	GO:0006096	Glycolytic process	lpdV, lpd, gap, aceF, pgi, eno, bkdB, gpmI
	GO:0009083	Branched-chain amino acid catabolic process	bkdA1, bkdA2, mmsB
	GO:0006412	Translation	rpmB, gatB, rpsA, rpsB, rplK, rplE, rplX, rpsH, frr, rplJ, rplQ, rpsN, rpmC, rplP, rplN, rplY, rpsQ, rpsF, rplT, rpsC, rplV, rplS, rpsT, rpsI, rpsS, rplM, rpsK, rplD, rplC, rpsM, rplW, rplO, rpsG, rpsJ, rplU, rpsD, rpsL, rpsE, rplR
	GO:0009116	Nucleoside metabolic process	upp, purF
	GO:0006730	One-carbon metabolic process	folE2, metK, ahcY
	GO:0000028	Ribosomal small subunit assembly	rpsS, rpsK, era, rpsG
	GO:0015986	ATP synthesis coupled proton transport	atpG, atpA, atpH, atpC
	GO:0045454	Cell redox homeostasis	lpdV, lpd, sthA, trxA, gor
	GO:0032790	Ribosome disassembly	infC, fusA, fusB
	GO:0006526	Arginine biosynthetic process	aruC, argJ, carA
Cellular Components	GO:0022627	Cytosolic small ribosomal subunit	rpsS, rpsB, rpsK, rpsH, rpsG, rpsA, rpsQ, rpsF, rpsI, rpsE, rpsC
	GO:0022625	Cytosolic large ribosomal subunit	rpmB, rplS, rplM, rplK, rplE, rplC, rplX, rplJ, rplB, rplQ, rplW, rplO, rpmC, rplP, rplN, rplY, rplF, rplT, rplR, rplV
	GO:0005840	Ribosome	rplM, rplD, rpsG, rplU, rpsL
	GO:0015935	Small ribosomal subunit	rpsM, rpsT, rpsN, rpsJ, rpsI, rpsL, rpsD
	GO:0045261	Proton-transporting ATP synthase complex, catalytic core F(1)	atpG, atpA, atpH, atpC
	GO:0015934	Large ribosomal subunit	rplK, rplJ, rplQ, rplV
	GO:0005829	Cytosol	bioD, hupA, vfr, PSPA7, adk, acnB, ribB, gpmI, ppa, arcC, alaS, pyrG, gcvH2, metG, thrS, nusG, frr, metK, era, gap, dxs, htpG, ilvC, upp, dapF, hemB, aspC, davT, algR, infC, hfq, sucC, rpsT, sthA, grpE, pgi, proS, tyrS, fusB, lysS, ahcY, rpsM, qor, bfr, fusA, hupB, phoP, trxA
	GO:0005737	Cytoplasm	lpdV, clpB, gyrA, groES, lpd, xseA, adk, efp, gcvH2, tsf, folE2, carA, frr, katA, argS, rlmN, upp, gor, purF, purA, aruC, pepA, phzF1, argJ, glnA, bkdB, clpP1, pyrD, proC, tig, qor, aceF, ftsZ, ndk, trxA, clpP2, fadA
	GO:0042709	Succinate–CoA ligase complex	sucD, sucC

Genes highlighted in red and blue represent the upregulation and downregulation of respective proteins in UMB treated cells.