TABLE 4.
IgG and NAbs levels stratified by vaccine formulation and by genotypes.
| Vaccine | Gene | Genotype(s) | p values | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TP53 | CC | CG | GG | CC+CG | p 1 | p 2 | p 3 | |||||
| Mean ± SD | (n) | Mean ± SD | (n) | Mean ± SD | (n) | Mean ± SD | (n) | |||||
| mRNA based | IgG (T1) | 33445.9 ± 20469.0 | (33) | 34205.5 ± 18659.6 | (22) | 19542.6 ± 10019.9 | (7) | 33.749.7 ± 19591.6 | (55) | 0.04 | 0.03 | 0.03 |
| NAbs (T1) | 50.56 ± 26.32 | 48.14 ± 24.56 | 37.2 ± 6.10 | 49.6 ± 25.43 | 0.09 | 0.12 | 0.10 | |||||
| IgG (T2) | 16135.8 ± 12326.0 | (37) | 17048.7 ± 11.115.4 | (21) | 10149.2 ± 4568.9 | (8) | 16466.3 ± 10164.6 | (58) | 0.09 | 0.05 | 0.07 | |
| NAbs (T2) | 28.24 ± 18.23 | 30.21 ± 16.40 | 18.45 ± 9.25 | 28.96 ± 15.56 | 0.07 | 0.03 | 0.05 | |||||
| Vector based | IgG (T1) | 13110.3 ± 14109.9 | (21) | 13356.7 ± 13117.0 | (15) | 8269.9 ± 4228.8 | (4) | 13212.9 ± 13513.1 | (36) | 0.25 | 0.23 | 0.23 |
| NAbs (T1) | 34.78 ± 24.11 | 32.46 ± 26.20 | 25.05 ± 9.79 | 33.81 ± 24.66 | 0.22 | 0.29 | 0.24 | |||||
| IgG (T2) | 4857.9 ± 2829.4 | (11) | 3018.5 ± 2452.5 | (10) | 4491.1 ± 3489.1 | (6) | 3981.9 ± 2865.1 | (21) | 0.41 | 0.16 | 0.35 | |
| NAbs (T2) | 18.13 ± 12.69 | 11.13 ± 8.42 | 13.09 ± 3.66 | 14.80 ± 6.92 | 0.18 | 0.30 | 0.35 | |||||
| ABO | GG | GT | TT | GG + GT | p 1 | p 2 | p 3 | |||||
| Mean ± SD | (n) | Mean ± SD | (n) | Mean ± SD | (n) | Mean ± SD | (n) | |||||
| mRNA based | IgG (T1) | 33099.8 ± 18949.4 | (26) | 29217.9 ± 19115.7 | (30) | 42766.0 ± 20167.0 | (6) | 31020.2 ± 18965.9 | (56) | 0.13 | 0.06 | 0.06 |
| NAbs (T1) | 49.9 ± 23.22 | 44.55 ± 26.02 | 59.0 ± 19.06 | 47.05 ± 24.69 | 0.19 | 0.1 | 0.13 | |||||
| IgG (T2) | 14463.6 ± 9466.39 | (27) | 16444.8 ± 12638.99 | (29) | 16881.8 ± 12928.39 | (10) | 15489.6 ± 12543.13 | (56) | 0.26 | 0.46 | 0.36 | |
| NAbs (T2) | 26.60 ± 15.25 | 29.98 ± 18.47 | 23.92 ± 17.79 | 28.35 ± 18.26 | 0.32 | 0.18 | 0.22 | |||||
| Vector based | IgG (T1) | 13003.7 ± 15190.0 | (19) | 11749.0 ± 10670.7 | (20) | 26694.8 | (1) | 12360.2 ± 12909.0 | (39) | - | - | - |
| NAbs (T1) | 35.24 ± 25.51 | 30.56 ± 22.83 | 36.63 | 32.84 ± 23.97 | - | - | - | |||||
| IgG (T2) | 4337.7 ± 2955.2 | (12) | 3649.1 ± 2819.3 | (14) | 7426.9 | (1) | 3966.9 ± 2886.6 | (26) | - | - | - | |
| NAbs (T2) | 13.83 ± 7.58 | 14.20 ± 11.92 | 24.58 | 14.03 ± 11.79 | - | - | - | |||||
| ACE2 | A + AA | GA | G + GG | - | p 1 | p 2 | - | |||||
| Mean ± SD | (n) | Mean ± SD | (n) | Mean ± SD | (n) | - | - | |||||
| mRNA based | IgG (T1) | 42068.5 ± 28382.8 | (4) | 37513.2 ± 17940.6 | (14) | 23804.6 ± 18675.1 | (44) | - | - | 0.14 | 0.08 | - |
| NAbs (T1) | 75.2 ± 27.07 | 49.5 ± 19.98 | 40.6 ± 24.40 | - | - | 0.01 | 0.1 | - | ||||
| IgG (T2) | 30354.3 ± 17075.8 | (4) | 10689.3 ± 10472.1 | (14) | 11715.2 ± 10801.2 | (48) | - | - | 0.01 | 0.3 | - | |
| NAbs (T2) | 45.20 ± 26.44 | 24.56 ± 12.13 | 25.42 ± 17.16 | - | - | 0.04 | 0.3 | - | ||||
| Vector based | IgG (T1) | 8032.8 ± 5981.6 | (6) | 13638.1 ± 5015.8 | (6) | 8148.8 ± 15017.1 | (28) | - | - | 0.2 | 0.045 | - |
| NAbs (T1) | 22.44 ± 13.84 | 30.10 ± 12.64 | 25.71 ± 26.97 | - | - | 0.2 | 0.40 | - | ||||
| IgG (T2) | 1658.4 ± 2200.7 | (4) | 4460.4 ± 3853.8 | (4) | 2706.8 ± 2811.1 | (19) | - | - | 0.11 | 0.44 | - | |
| NAbs (T2) | 8.93 ± 7.98 | 13.73 ± 16.67 | 10.9 ± 8.98 | - | - | 0.29 | 0.21 | - | ||||
| APOE | Ɛ3 | Ɛ4 | - | - | p | - | - | |||||
| Mean ± SD | (n) | Mean ± SD | (n) | - | - | - | - | |||||
| mRNA based | IgG (T1) | 34546.8 ± 19466.4 | (50) | 22199.4 ± 15140.01 | (12) | - | - | - | - | 0.02 | - | - |
| NAbs (T1) | 53.0 ± 23.28 | 28.3 ± 18.17 | - | - | - | - | 0.0005 | - | - | |||
| IgG (T2) | 15959.0 ± 11646.0 | (58) | 13826.9 ± 9376.8 | (8) | - | - | - | - | 0.3 | - | - | |
| NAbs (T2) | 28.32 ± 17.28 | 23.06 ± 14.86 | - | - | - | - | 0.21 | - | - | |||
| Vector based | IgG (T1) | 12632.3 ± 12949.4 | (33) | 13125.7 ± 3936.1 | (7) | - | - | - | - | 0.4 | - | - |
| NAbs (T1) | 32.8 ± 22.69 | 33.8 ± 29.92 | - | - | - | - | 0.4 | - | - | |||
| IgG (T2) | 4210.0 ± 2922.17 | (22) | 3589.3 ± 2877.02 | (5) | - | - | - | - | 0.3 | - | - | |
| NAbs (T2) | 15.44 ± 10.68 | 9.9 ± 4.05 | - | - | - | - | 0.1 | - | - | |||
| HLA | CC + GG | CT + GT | - | - | p | - | - | |||||
| Mean ± SD | (n) | Mean ± SD | (n) | - | - | - | - | |||||
| mRNA based | IgG (T1) | 34249.0 ± 18.559.2 | (47) | 19186.7 ± 14.595.4 | (10) | - | - | - | - | 0.01 | - | - |
| NAbs (T1) | 50.6 ± 23.63 | 31.6 ± 21.32 | - | - | - | - | 0.015 | - | - | |||
| IgG (T2) | 15730.2 ± 11.709.5 | (49) | 11691.5 ± 6.372.8 | (10) | - | - | - | - | 0.14 | - | - | |
| NAbs (T2) | 27.13 ± 17.82 | 24.51 ± 11.44 | - | - | - | - | 0.33 | - | - | |||
| Vector based | IgG (T1) | 12084.9 ± 10.581.9 | (32) | 16000.3 ± 27.086.9 | (5) | - | - | - | - | 0.27 | - | - |
| NAbs (T1) | 32.17 ± 23.09 | 31.27 ± 34.84 | - | - | - | - | 0.46 | - | - | |||
| IgG (T2) | 3520.0 ± 2.550.8 | (21) | 6554.0 ± 3.069.7 | (4) | - | - | - | - | 0.099 | - | - | |
| NAbs (T2) | 13.2 ± 8.86 | 15.9 ± 7.46 | - | - | - | - | 0.2 | - | - | |||
IgG and NAbs levels are assessed as AU/mL and AU% respectively; p p 1 p 2 p 3 indicate the statistical mean comparisons among the different genotype subgroups. In bold significant p-values.