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. 2022 Nov 30;13:1058493. doi: 10.3389/fimmu.2022.1058493

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Copyright © 2022 Chen, Liu, Lu and Gu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlations of immune checkpoints and somatic mutation with BM-TME classifier in TCGA-LUAD cohort. (A) The differential expression levels of immune checkpoint genes among BM-TME classifier subgroups. (B) Waterfall plots depicting the mutation landscape of the top 15 genes with high mutation frequency. P-values on the right side displaying the significance of differences in 15 gene mutation frequencies between two BM-TME groups. (C) Kaplan–Meier curves of patients with LUAD divided by the CSMD3 mutation status and BM-TME classifier. (D) The distribution of TMB among different BM-TME classifier subgroups. *p<=0.05, **p<=0.01 and ***p<=0.001, respectively. ns, no significance.