FIG. 5.

Correlation of TS expression with virulence of transgenic L. major. L1G5 and L1D4 are subclones isolated by limiting dilution from a BALB/c lesion produced by infection with clone L1. (A) TS activity of parental L1 clone, subclones L1G5 and L1D4, and subclone L1D4 retransfected with TS-bearing plasmid pXG1a (L1D4-TS) and empty vector (L1D4-vector). (B) Time course of infection in BALB/c mice inoculated with subclones L1G5 and L1D4. (C) Time course of infection in BALB/c mice inoculated with subclones L1D4-TS and L1D4-vector. P.I., postinoculation.