Table 3.

Choice of Antiviral Agents in Chronic Hepatitis B

Drug	Treatment Duration	Potential Side Effects	Tolerability	Risk of Viral Resistance
PegIFNα	48 weeks	Flu-like symptoms, myalgia, headache, fatigue, weight loss, hair loss, injection site reactions, myelosuppression	Low	No
ETV	Long-term	Lactic acidosis (in decompensated cirrhosis)	High	Minimal to none
TDF	Long-term	Nephropathy, Fanconi syndrome, osteomalacia, lactic acidosis	High	Minimal to none
TAF	Long-term	Lactic acidosis	High	Minimal to none