Figure 5.

Inhibitory effect of flusalazine against PGE₂ level on acetic acid-induced writhing response in mice. At 20 min after intraperitoneal injection of 1% acetic acid in normal saline, the mice were killed by cervical dislocation. Flusalazine (25, 100, 250 mg/kg), aspirin (100, 300 mg/kg), celecoxib (100, 300 mg/kg), indomethacin (10 mg/kg), and vehicle (1% Lutrol F-127 in water) were administered orally 30 min prior to acetic acid injection. The lavage fluid in the peritoneal cavity was collected and PGE₂ was quantified by ELISA. Data are expressed as mean ± S.E.M. *p<0.05 versus vehicle group compared by one-way ANOVA followed by Tukey.