Table 1.
Results for the lead risk variants at 17 novel loci identified in cross-ancestry meta-analyses of GWAS data
| Variants | Loci | Nearest gene | Gene region | Allelesa | EAFb | OR (95% CI) | pc | I2, % | p_het |
|---|---|---|---|---|---|---|---|---|---|
| Overall | |||||||||
| rs727477 | 2p22.1 | SLC8A1 | Intron | G/T | 0.36 | 0.97 (0.96, 0.98) | 2.85 × 10−8 | 52.1 | 0.03 |
| rs3010266 | 5q13.2 | LINC02056 | 8.5 kb from 5′ | A/G | 0.24 | 0.96 (0.95, 0.98) | 3.56 × 10−8 | 0 | 0.83 |
| rs6890591d | 5q35.2 | CPEB4 | 3.3 kb from 3′ | A/T | 0.38 | 0.97 (0.96, 0.98) | 3.25 × 10−8 | 50.5 | 0.04 |
| rs3829964 | 6p21.2 | CDKN1A | Intron | T/C | 0.47 | 0.97 (0.96, 0.98) | 4.61 × 10−9 | 0 | 0.46 |
| rs74392007 | 6q22.31 | HSF2 | 5.4 kb from 5′ | T/C | 0.12 | 1.05 (1.03, 1.07) | 1.55 × 10−8 | 0 | 0.93 |
| rs3778663 | 6q27 | AFDN | Intron | A/G | 0.13 | 1.06 (1.04, 1.07) | 8.51 × 10−9 | 0 | 0.69 |
| rs17167576 | 7p21.2 | AC005019.3e | 5.5 kb from 3′ | A/T | 0.37 | 1.03 (1.02, 1.04) | 6.93 × 10−9 | 47.2 | 0.05 |
| rs3988353 | 8p22 | PCM1 | Intron | CT/C | 0.42 | 1.03 (1.02, 1.04) | 4.32 × 10−8 | 0 | 0.81 |
| rs1937680 | 10q21.1 | PRKG1 | Intron | C/A | 0.36 | 1.03 (1.02, 1.04) | 8.18 × 10−9 | 1.3 | 0.42 |
| rs11354045 | 11q23.1 | ALG9 | Intron | CT/C | 0.35 | 1.03 (1.02, 1.04) | 2.68 × 10−8 | 22.3 | 0.25 |
| rs36028244 | 11q23.3 | PCSK7 | Intron | C/CTTA | 0.07 | 1.06 (1.04, 1.08) | 1.77 × 10−8 | 0 | 1.00 |
| rs3809114 | 12q13.3 | INHBE | 5′ UTRf | G/A | 0.47 | 0.97 (0.96, 0.98) | 2.33 × 10−8 | 37.8 | 0.12 |
| rs956006 | 15q22.2 | TLN2 | Intron | T/C | 0.32 | 1.03 (1.02, 1.05) | 3.54 × 10−8 | 1.7 | 0.42 |
| rs4797754 | 18p11.21 | LDLRAD4 | Intron | G/C | 0.31 | 1.03 (1.02, 1.05) | 2.08 × 10−8 | 0 | 0.50 |
| rs112208395 | 20q11.23 | PHF20 | Intron | C/CT | 0.14 | 1.05 (1.03, 1.07) | 4.11 × 10−8 | 0 | 0.96 |
| rs74157632g | 10q26.11 | DENND10 | Missense | G/A | 0.05 | 0.86 (0.81, 0.90) | 1.41 × 10−8 | 0 | 1.00 |
| ER-negative | |||||||||
| rs2123844 | 17p13.2 | ZZEF1 | Intron | A/C | 0.07 | 1.13 (1.09, 1.18) | 2.81 × 10−10 | 37.4 | 0.16 |
a
Effect allele/reference allele.
b
Effect allele frequency.
c
Unless otherwise specified, p derived from meta-analyses using fixed-effects model.
d
Identified using cross-ancestry meta-regression (Table S6). The p derived from cross-ancestry fixed-effects model is (Table S2).
e
AC005019.3 (ENSG00000224330) does not have a gene symbol in HUGO yet.
f
UTR, untranslated region.
g
Identified in Asian-specific GWASs. The p for cross-ancestry fixed-effects model is (Table S2).