Table 1.

Posterior probability and positive likelihood ratio values (reduced to four significant digits) that define the varying strengths of evidence in this study for the PP3 and BP4 criteria

Criterion	Evidence Strength	Posterior probability of pathogenicity (for PP3) and benignity (for BP4)	Positive likelihood ratio	Reciprocal of positive likelihood ratio
PP3	very strong	0.9811	1,124:1	0.0009:1
	strong	0.6073	33.53:1	0.0298:1
	moderate	0.2108	5.790:1	0.1727:1
	supporting	0.0999	2.406:1	0.4156:1
BP4	supporting	0.9812	0.4156:1	2.406:1
	moderate	0.9921	0.1727:1	5.790:1
	strong	0.9986	0.0298:1	33.53:1
	very strong	1.0000	0.0009:1	1,124:1