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. 2022 Nov 28;19(11):894–927. doi: 10.11909/j.issn.1671-5411.2022.11.008

Table 1. Clinical questions on the management of cardiovascular risk factors in the older population.

Sedentariness Alcohol
What are sedentariness and physical activity and how are they measured? What are safe alcohol limits in older people?
Are older people more sedentary? How can the cardioprotective effect of alcohol be explained?
Is sedentariness compensated by physical activity? What are safe alcohol limits in older people with ischemic heart disease?
What is the importance of sedentariness in cardiovascular risk in older adults? How much does alcohol consumption contribute to heart disease in older people?
How much does sedentariness contribute to all-cause mortality in older adults? How does alcohol consumption affect peripheral vascular disease in older adults?
How much does sedentariness influence cardiovascular mortality in older adults? Does alcohol affect the risk of AF in older adults?
How much does exercise reduce cardiovascular risk in older adults? How does alcohol consumption influence the risk of stroke in older adults?
How do frailty or functional status worsen prognosis of cvrf in older adults? Does alcohol consumption influence the prognosis of AF in older adults?
Do CVRF worsen prognosis in elderly patients with frailty or functional decline? What is the relationship between alcohol consumption and hypertension in older adults?
Is it worth reducing sedentariness in older adults? What is the relationship between alcohol consumption and dm in older adults?
How can sedentariness be decreased in older adults? How much does alcohol consumption influence mortality in older adults with heart failure?
What physical activity is recommended in older adults and how should it be prescribed? How does alcohol interact with drug therapy for CVRF?
Hypertension Obesity and metabolic syndrome
What are the SBP and DPB targets in older patients with hypertension? How much/how do obesity and MS influence cardiovascular risk in older adults?
How does frailty influence the management of hypertension in older adults? What is the contribution of obesity/MS to cardiovascular mortality in older adults?
How does frailty or functional status worsen prognosis of hypertension in older adults? What is the contribution of obesity/MS in cardiovascular morbidity in older adults?
Does frailty or functional decline worsen prognosis of hypertension in older patients? Does frailty or functional decline worsen outcome of obesity in older patients?
What effect does exercise have in older patients with hypertension? What is the non-pharmacological treatment of older people with obesity and/or MS?
Do comorbidity and other factors influence the management of hypertension? What are the particular features of the management of older people with obesity and frailty or functional decline?
What is the most effective drug therapy for hypertension in older adults? Are treatment goals the same as in young adults?
How do persons older than 80 years respond to antihypertensive treatment? How can a healthy diet be encouraged in older adults?
What are the specific therapeutic options for the treatment of hypertension in older adults?
What are the adverse effects of drug therapy for hypertension in older adults? Dyslipidemia
What are the most common events in frail or dependent older adults with hypertension? What are the considerations of the management of dislipidemia in older patients?
Are high cholesterol values a sign of healthy aging?
Type 2 diabetes mellitus Are treatment targets the same in older and younger adults?
What are the therapeutic targets in older people with DM2? How does the management of dyslipidemia in older adults differ from that in younger adults?
What is the therapeutic target in older adults with frailty or functional decline and DM2? What are the specific considerations of the management of dyslipidemia in older adults with frailty and functional decline?
Does frailty or functional decline worsen prognosis of DM2 in older patients?
What adverse effects can be expected with statin therapy in older adults?
How does frailty or functional status worsen prognosis of DM2 in older adults? Is statin therapy indicated for cardiovascular disease prevention in older adults?
Review of pharmacological recommendations: metformin Does statin therapy prevent cardiovascular risk and mortality in older adults with or without DM2?
Review of pharmacological recommendations in older people with DM2: pioglitazone What is the effect of pravastatin use versus routine care in older adults?
Review of pharmacological recommendations in older people with DM2: sulfonylureas
Review of pharmacological recommendations in older people with DM2: meglitinides Smoking
Review of pharmacological recommendations in older people with DM2: glp-1 receptor antagonist Does smoking affect quality of life in older adults?
Review of pharmacological recommendations in older people with DM2: dpp4 inhibitors Does smoking affect cardiovascular disease in older adults?
Review of pharmacological recommendations in older people with DM2: alpha-glucosidase inhibitors Does smoking influence cognition in older adults?
Review of pharmacological recommendations in older people with DM2: insulin Does smoking affect mortality in older adults?
What is the risk of overtreatment in older people with DM2? How do frailty or functional decline worsen outcome of smoking in older patients?
How do these therapeutic options modify comorbidities (CKD, HF)? Do frailty or functional decline worsen outcome of smoking in older patients?
What differences are there between intensive versus standard glycemic control in older adults? Therefore, is smoking cessation beneficial in older age?
Are smoking cessation interventions effective in older adults?