Table 8. Review of studies on alcohol intake in the elderly.
| Studies | Quality assessment | Summary of findings | Quality | |||||||||
| Ref | N | Study design | Limitations | Inconsistency | Indirectness | Imprecision | Imprecision | Relative effect estimates | Absolute effect estimates | |||
| CS: Cohort study; HR: Hazard ratio; I: Important; NA: not applicable; OBS: observational study; OR: odds ratio; Re: bibliography reference annex 1; RR: relative risk; sig: significant; RV: review; U: undetected; UV: Unavailable; VI: Very Important; Quality: quality assessed according to GRADE methodology. | ||||||||||||
| How is alcohol intake evaluated in the elderly? | ||||||||||||
| 117 | 3 058 | OBS | I | U | U | U | U | NA | NA | Low | ||
| 118 | 3 815 | OBS | I | U | I | U | U | Increased likelihood of medication-alcohol intake | UV | Low | ||
| 119 | 1 500 | RV | I | ND | NA | NA | U | NA | NA | High | ||
| Is it safe to consume alcohol in the elderly? | ||||||||||||
| 120 | 542 | OBS | VI | U | U | U | U | RR -13% Hypertension (alcohol intake vs abstinence) | UV | Very low | ||
| 121 | NA | RV | VI | ND | NA | ND | SI | NA | NA | Very low | ||
| How does alcohol intake influence cardiovascular risk in the elderly? | ||||||||||||
| 122 | NA | RV | VI | U | NA | NA | U | NA | NA | Very low | ||
| 123 | 1 896 | OBS | I | U | U | U | U | Alcohol intake vs abstinence: healthy values (fibrinogen, HDL cholesterol, apo A-liporotein, insulin) and unhealthy (LDL cholesterol. blood pressure) | UV | Low | ||
| 124 | 4 655 | OBS | I | U | U | U | U | HR 0.5 (0.3-0.9) (h) HR 0.7 (0.4-1.1) (m) |
UV | Very low | ||
| 125 | 983 | OBS | I | U | U | U | U | RR 0.69 (former consumers) RR 0.54 (mild consumer) RR 0.44 (moderate consumer) RR 0.21 (high consumer) |
UV | Low | ||
| 126 | 4 410 | OBS | I | U | U | I | U | RR 0.90 (<1 alcohol intake/week) RR 0.93 (1-6 alcohol intake/week) RR 0.76 (7-14 alcohol intake/week) RR 0.58 (>14.alcohol intake/week) |
UV | Low | ||
| HOW COULD THE CARDIOPROTECTIVE EFFECT OF ALCOHOL be justified? | ||||||||||||
| 127 | 553 | OBS | VI | U | U | U | U | No significant differences alcohol-Systolic blood pressure significant differences alcohol-Dyastolic blood pressure |
UV | Low | ||
| 128 | 4 247 | OBS | I | U | U | U | U | Mild consumer: < intimate-medium thickness High consumer: > intimate-medium thickness |
UV | Low | ||
| How does alcohol influence heart failure? | ||||||||||||
| 129 | 1 332 | OBS | I | MI | U | U | U | Consumptium vs no consumptium: HR +1.19 (mortality including heart failure) HR -0.79 (mortality without including heart failure) |
UV | Low | ||
| 130 | 2 235 | OBS | I | U | U | U | U | Mortality in consumers vs abstinents: HR 0.79 mild consumer / HR 0.53 moderate consumer and risk of heart failure: HR 0.81 mild consumer / HR 0.75 moderate consumer |
UV | Low | ||
| 131 | 6 083 | OBS | I | U | U | I | U | No relation between consume and heart failure | UV | Low | ||
| 132 | 4 490 | OBS | I | U | U | U | U | HR 0.77 lower risk in mild consume | UV | Low | ||
| 133 | 5 595 | OBS | I | U | U | U | U | Risk for heart faliure: HR 0.82 (mild consumers vs abstinents) HR 0.66 (moderate consumers vs abstinents) HR 1.15 (former consumers vs abstinents) |
UV | Low | ||
| 134 | 5 888 | OBS | I | U | U | I | U | Average survival: + 383 days (moderate consumers vs abstinents) |
UV | Low | ||
| Do the elderly benefit from alcohol cessation treatments? | ||||||||||||
| 135 | NA | RV | VI | U | ND | U | U | UV | NA | Very low | ||
| 136 | 51 | OBS | I | U | U | U | U | UV | UV | Very low | ||
| 137 | 925 | CS | VI | U | I | I | U | Abstinence 5 years: 52% (> 50 years) 40% (<50 years) | NA | Very low | ||