Table 4. Variable analysis of factors that may influence inflammatory markers post TAVR for patients ≥ 80 years.
| WBC at 24 h | Abs. neutrophils at 24 h | Abs. lymphocytes at 24 h | NL ratio at 24 h | |||||||||
| (Median [IQR]) | P-value | (Median [IQR]) | P-value | (Median [IQR]) | P-value | (Median [IQR]) | P-value | |||||
| Data are presents as median (interquartile range). Continues variables between the various study groups were tested for normality by Shapiro-Wilk test and when abnormal distribution was found Mann-Whitney test was performed, when the distribution was normal t - test was used. *Correlation between two Continues variables was tested by Pearson Correlation. Abs: absolute; AI: aortic insufficiency; AV: aortic valve; AVA: aortic valve area; BEV: balloon expandable valve; CABG: coronary artery bypass grafting; LVEF: left ventricle ejection fraction; NL: neutrophils to lymphocytes; STS: Society of Thoracic Surgeons; SEV: self-expandable valve; TAVR: transcatheter aortic valve replacement; WBC: white blood cells. | ||||||||||||
| Gender | Females | 9.53 (7.69-11.8) | 0.637 | 7.8 (5.7-9.67) | 0.453 | 1 (0.7-1.4) | 0.385 | 7.12 (4.78-11.33) | 0.756 | |||
| Males | 9.2 (7.6-11.5) | 7 (5.7-10) | 0.99 (0.7-1.3) | 7.22 (5.15-12.66) | ||||||||
| Age*, yrs | 0.018 | 0.750 | −0.050 | 0.932 | 0.035 | 0.525 | −0.023 | 0.680 | ||||
| Body mass index*, kg/m2 | 0.087 | 0.174 | 0.053 | 0.413 | 0.127 | 0.047 | −0.070 | 0.275 | ||||
| HTN | No | 9.6 (6.8-15.3) | 0.702 | 7.9 (4.9-12.5) | 0.567 | 0.9 (0.7-1.2) | 0.430 | 8.77 (5.56-15.62) | 0.271 | |||
| Yes | 9.4 (7.7-11.6) | 7.4 (5.7-9.6) | 1 (0.7-1.3) | 7.21 (4.9-11.37) | ||||||||
| Diabetes | No | 9.5 (7.7-12.22) | 0.216 | 7.7 (5.824-10.27) | 0.133 | 0.9 (0.7-1.3) | 0.076 | 8 (5.2-12.83) | 0.013 | |||
| Yes | 9.1 (7.5-11.3) | 7 (5.5-9.1) | 1.1 (0.79-1.4) | 6.72 (4.66-9.344) | ||||||||
| Dyslipemia | No | 9.25 (7.62-13.4) | 0.665 | 7.85 (5.72-10.6) | 0.375 | 0.9 (0.71-1.2) | 0.333 | 8.07 (5.18-12.2) | 0.144 | |||
| Yes | 9.4 (7.65-11.55) | 7.4 (5.7-9.48) | 1 (0.7-1.4) | 6.97 (4.87-11.28) | ||||||||
| Smoker | No | 9.4 (7.69-11.8) | 0.802 | 7.43 (5.7-9.79) | 0.757 | 1 (0.7-1.33) | 0.938 | 7.21 (4.9-11.85) | 0.909 | |||
| Yes | 9.61 (7.6-11.4) | 7.445 (5.9-9.51) | 1.1 (0.6-1.3) | 7.77 (5.26-10.83) | ||||||||
| A. fibrillation | No | 9.5 (7.62-12) | 0.375 | 7.505 (5.7-10.2) | 0.209 | 1 (0.7-1.3) | 0.835 | 7.65 (5-12) | 0.293 | |||
| Yes | 9.2 (7.5-11.1) | 7 (5.4-9.0415) | 1 (0.7-1.4) | 6.8 (4.78-11.33) | ||||||||
| CAD | No | 9.39 (7.5-11.7) | 0.743 | 7.4 (5.7-9.79) | 0.916 | 0.99 (0.7-1.3) | 0.544 | 7.18 (4.9-11.8) | 0.993 | |||
| Yes | 9.6 (7.8-11.6) | 7.4 (5.8-9.4) | 1 (0.7-1.315) | 7.45 (4.97-11.46) | ||||||||
| PVD | No | 9.4 (7.61-11.7) | 0.860 | 7.49 (5.7-9.795) | 0.712 | 1 (0.7-1.33) | 0.932 | 7.17 (4.86-12.14) | 0.865 | |||
| Yes | 9.39 (7.8-11.65) | 6.995 (5.8-9.5) | 1 (0.76-1.2542) | 7.66 (5.64-10.05) | ||||||||
| S/P MI | No | 9.4 (7.6-11.7) | 0.836 | 7.43 (5.7-9.7) | 0.741 | 1 (0.7-1.315) | 0.821 | 7.14 (4.95-11.78) | 0.832 | |||
| Yes | 9.53 (7.7-11.4) | 7.2 (5.9-9.3) | 1 (0.8-1.3) | 7.85 (5.02-11.34) | ||||||||
| S/P CVA-TIA | No | 9.345 (7.6-11.68) | 0.280 | 7.355 (5.7-9.67) | 0.270 | 1 (0.7-1.4) | 0.228 | 7.18 (4.86-11.57) | 0.196 | |||
| Yes | 9.9 (8.4-12.1) | 7.9 (6.5-11) | 1 (0.7-1.2) | 7.86 (5.75-12.14) | ||||||||
| Pacemaker | No | 9.4 (7.7-11.9) | 0.355 | 7.415 (5.8-10) | 0.288 | 1 (0.7-1.355) | 0.555 | 7.19 (4.89-12.07) | 0.777 | |||
| Yes | 9.41 (7.4-10.75) | 7.12 (5.2-9.1) | 0.9 (0.7-1.2) | 7.4 (5.37-10.43) | ||||||||
| S/P CABG | No | 9.3 (7.59-11.5) | 0.645 | 7.1 (5.5-9.51) | 0.531 | 1.03 (0.7-1.33) | 0.733 | 6.72 (4.76-11.16) | 0.466 | |||
| Yes | 9.695 (8.4-11.7) | 7.315 (6.75-9.85) | 0.9198 (0.665-1.29) | 8.06 (5.79-10.07) | ||||||||
| STS score* | 0.234 | 0.323 | 0.412 | 0.52 | 0.214 | 0.71 | 0.165 | 0.568 | ||||
| Baselines Echo | ||||||||||||
| *LVEF (%) | 0.094 | 0.095 | 0.077 | 0.170 | 0.090 | 0.110 | −0.040 | 0.485 | ||||
| *AVA, cm2 | −0.052 | 0.377 | −0.070 | 0.239 | 0.107 | 0.073 | −0.113 | 0.057 | ||||
| *AV gradient mean, mmHg | 0.041 | 0.640 | 0.037 | 0.694 | −0.058 | 0.509 | 0.056 | 0.524 | ||||
| *Septum thickness, mm | 0.103 | 0.067 | 0.091 | 0.107 | −0.029 | 0.606 | 0.080 | 0.161 | ||||
| SEV vs. BEV | SEV | 9.79 (7.8-12.1) | 0.040 | 7.74 (5.9-10.2) | 0.046 | 1 (0.7-1.3) | 0.417 | 7.65 (5-12.2) | 0.094 | |||
| BEV | 9.1 (7.1-11.1) | 7.1 (5.4-9.4) | 1 (0.71-1.4) | 6.83 (4.78-10.44) | ||||||||
| *Contrast volume, mL | 0.152 | 0.006 | 0.174 | 0.002 | −0.038 | 0.490 | 0.109 | 0.051 | ||||
| *Time, min | 0.145 | 0.009 | 0.213 | < 0.001 | −0.209 | < 0.001 | 0.263 | < 0.001 | ||||
| Post dilatation | No | 9.4 (7.6-11.7) | 0.577 | 7.31 (5.7-9.7) | 0.419 | 1 (0.76-1.4) | 0.085 | 7.06 (4.87-11.35) | 0.159 | |||
| Yes | 9.65 (7.66-11.9) | 8 (5.995-9.995) | 0.9396 (0.6-1.2) | 8.03 (5.18-12.57) | ||||||||