Table 3. Description of hypertension-mediated organ damage.
| Total cohort (n = 938) |
Age < 65 years (n = 748) |
Age ≥ 65 years (n = 190) |
P-value | |
| Data are presented as n (%) or median [interquartile range]. eGFR: estimated glomerular filtration rate; HMOD: hypertension-mediated organ damage; LVH: left ventricular hypertrophy; LVMI2.7: left ventricular mass indexed to height to the allometric power of 2.7; PWV: pulse wave velocity; RaVL: R wave in aVL lead; TTE: transthoracic echocardiography. | ||||
| Kidney | ||||
| eGFR < 60 mL/min | 74 (7.9%) | 37 (4.9%) | 37 (19.5%) | < 0.001 |
| Albuminuria > 30 mg/24 h | 287 (30.6%) | 212 (28.3%) | 75 (39.5%) | 0.003 |
| ≥ 1 kidney HMOD | 323 (34.4%) | 227 (30.3%) | 96 (50.5%) | < 0.001 |
| Heart | ||||
| NT-proBNP, pg/mL | 72.6 [33.5-156] | 58.1 [29.1-121.8] | 152.5 [80.3-390.5] | < 0.001 |
| TTE LVMI2.7, g/m2.7 | 52.4 [40.0-63.0] | 51.0 [38.3-61.3] | 60.8 [49.8-75.4] | < 0.001 |
| TTE LVH | 378 (49.0%) | 287 (45.0%) | 91 (68.4%) | < 0.001 |
| RaVL > 1.0 mV | 203 (21.8%) | 141 (19.0%) | 62 (32.6%) | < 0.001 |
| Sokolow-Lyon > 3.5 mV | 153 (16.3%) | 130 (17.4%) | 23 (12.1%) | 0.079 |
| Cornell | 117 (12.5%) | 87 (11.6%) | 30 (15.8%) | 0.121 |
| ECG LVH | 343 (36.6%) | 260 (34.8%) | 83 (43.7%) | 0.023 |
| ≥ 1 heart HMOD | 527 (56.2%) | 397 (53.1%) | 130 (68.4%) | < 0.001 |
| Vessels | ||||
| Pulse pressure, mmHg | 60 [50-67] | 56 [49-63] | 70 [63-84] | < 0.001 |
| Pulse pressure > 60 mmHg | 448 (47.8%) | 290 (38.8%) | 158 (83.2%) | < 0.001 |
| PWV, m/s | 10.0 [8.7-11.9] | 9.5 [8.4-11.2] | 12.6 [10.9-14.8] | < 0.001 |
| PWV > 10 m/s | 402 (50.5%) | 266 (41.2%) | 136 (90.1%) | < 0.001 |
| ≥ 1 vessel HMOD | 597 (46.6%) | 417 (55.7%) | 180 (94.7%) | < 0.001 |
| Number of HMOD | 1.3 ± 0.9 | 1.2 ± 0.9 | 2.1 ± 0.8 | < 0.001 |
| ≥ 1 HMOD | 728 (77.6%) | 545 (72.9%) | 183 (96.3%) | < 0.001 |