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. 2022 Nov 28;19(11):853–866. doi: 10.11909/j.issn.1671-5411.2022.11.002

Figure 2.

Figure 2

7,8-DHF restored pressure overload-induced compensated cardiac hypertrophy.

(A): Representative pictures of mouse hearts; (B): HW, TL, and HW/TL in sham, TAC surgery for 4 weeks and 7,8-DHF (5 mg/kg per day)-treated mice. N = 9 in each group. (C): Representative images of echocardiography. (D): EF, FS, LVPW,s, LVPW,d, LVV,s, LVV,d, LVID,s, and LVID,d in sham, TAC and 7,8-DHF-treated mice. N = 10 for the sham group, n = 13 for the TAC and +7,8-DHF groups. Data are expressed as mean ± SE. *P < 0.05 vs. sham, #P < 0.05, ##P < 0.01 vs. TAC. EF: ejection fraction; FS: fractional shortening; HW: heart weight; LVID,d: end-diastolic left ventricular internal diameter; LVID,s: end-systolic left ventricular internal diameter; LVPW,d: left ventricular end-diastolic posterior wall thickness; LVPW,s: left ventricular end-systolic posterior wall thickness; LVV,d: end-diastolic left ventricular volume; LVV,s: end-systolic left ventricular volume; 7,8-DHF: 7,8-dihydroxyflavone; TL: tibia length; TAC: transverse aortic constriction.