Figure 3.

7,8-DHF relieved cardiac injury in cardiac hypertrophy mice.

(A & B): Histological analyses of HE staining in the ventricles of mice in the sham, TAC surgery for 4 weeks, and 7,8-DHF (5 mg/kg per day)-treated groups; (C): representative western-blot bands and quantification of ANP, n = 6 in each group; (D): wheat germ agglutinin staining and quantification of average cross-sectional areas; 18 pictures of 3 mice in each group; (E): transmission electron microscopy and quantification of the diameter and roundness of mitochondria in the ventricles of mice, 9 pictures of 3 mice in each group. Data are expressed as mean ± SE. ^**P < 0.01 vs. sham, ^##P < 0.01 vs. TAC. 7,8-DHF: 7,8-dihydroxyflavone; TAC: transverse aortic constriction.