TABLE 4.
Antimicrobial activities of truncated peptides derived from rabbit CAP18a
| Peptide | MIC (μM) for:
|
|||||||
|---|---|---|---|---|---|---|---|---|
|
E. coli ML-35p
|
P. aeruginosa MR3007
|
MRSA ATCC 33591
|
S. aureus 930918-3
|
|||||
| Low salt | High salt | Low salt | High salt | Low salt | High salt | Low salt | High salt | |
| CAP18 | 0.05 | 0.09 | 0.04 | 0.36 | 1.90 | 1.40 | 0.41 | 0.63 |
| CAP1822 | 0.05 | 0.94 | 0.37 | 4.20 | 4.50 | >43.7 | 4.40 | >43.7 |
| CAP1821a | 0.88 | 0.15 | 0.27 | 0.34 | 7.40 | >95 | 0.69 | 0.84 |
| CAP1818 | 1.00 | 0.22 | 1.30 | 10.3 | 6.50 | >110 | 4.30 | 12.7 |
| CAP1815a | 0.11 | 0.37 | 0.80 | 2.80 | >130 | >130 | 0.95 | 1.17 |
| CAP1819 | 0.14 | 6.50 | 3.90 | 9.50 | 1.60 | >28.1 | 2.10 | >28.1 |
| CAP1821b | 0.90 | 0.20 | 1.10 | 9.20 | 4.00 | >98.0 | 6.40 | >98 |
| CAP1813 | 14.6 | >160 | >50.9 | >160 | >160 | >160 | >160 | >160 |
| CAP1815b | 0.92 | >143 | >45.4 | >143 | >143 | >143 | >143 | >143 |
| CAP1817 | 4.9 | 0.97 | 2.6 | >127 | >127 | >127 | >127 | >127 |
a
Data are MICs determined by the radial-diffusion assay performed with low-salt (no NaCl) and high-salt (100 mM NaCl) underlays.