TABLE 6.

Relative time for killing of P. aeruginosa PAO1 by several antimicrobial peptides and tobramycin^a

Antimicrobial compound	Concn (μg/ml)	Half time of killing (min)
mCRAMP	16	7.6 ± 3.5
rCRAMP	30	13.9 ± 2.8
SMAP29	2	2.3 ± 0.8
FALL39	24	22.7 ± 4.7
LL37	36	62.0 ± 26.3
CAP18	10	4.0 ± 1.4
CAP1821a	6	9.2 ± 3.4
CAP1818	10	19.5 ± 8.2
CAP1815a	15	32.5 ± 13.5
CAP1822	14	9.8 ± 2.5
CAP1819	16	8.0 ± 1.6
CAP1817	23	5.2 ± 2.1
Tobramycin	0.06	38.9 ± 4.5

^aAntimicrobial agents were used at a concentration 10 times their EC₅₀ against P. aeruginosa PAO1 at 25 mM ionic strength (Table 1). Bacteria were incubated with the compound, and luminescence was measured at 1.5-min intervals. The half time of killing is the time at which luminescence was decreased to half its original value. Data are mean ± standard error of the mean (n = 3) for each compound.