Physiological stimuli and cellular regulators of endothelial TRPV4 channel activity. TRPV4, transient receptor potential vanilloid 4; GqPCR, Gq protein-coupled receptors; ATP, adenosine triphosphate; CYP, cytochrome P450; Src, Src family kinases; PKA, protein kinase A; PKC, protein kinase C; SGK-1, serine/threonine kinase-1; EET, epoxyeicosatrienoic acid; PLA2, phospholipase A2; PLC, phospholipase C; DAG, diacylglycerol; PUFA, ω-polyunsaturated fatty acids; H2S, hydrogen sulfide; ACh, acetylcholine.