Table 1.

Pharmacological agonists and antagonists of TRPV4 channels.

Agonists	Species	Potency (EC50)	References
GSK1016790A	Rat, mouse, human	~10nM (Dunn, Hill-Eubanks, Liedtke, & Nelson, 2013; Thorneloe et al., 2008)	Marziano et al. (2017), Phuong et al. (2017), Sonkusare et al. (2012), Sonkusare et al. (2014), Thorneloe et al. (2012), Zhang, Papadopoulos, and Hamel (2013), Zhang et al. (2018)
RN1747	Mouse	~700 nM (Vincent et al., 2009)	Marziano et al. (2017)
4α-phorbol 12,13-didecanoate	Mouse, rat	~400nM (Watanabe, Davis, et al., 2002)	Hartmannsgruber et al. (2007), Kohler et al. (2006), Marrelli, O’Neil, Brown, and Bryan (2007), Vriens et al. (2005), Watanabe, Vriens, et al. (2002)
Antagonists	Species	Potency (IC50)	References
GSK2193874	Human, canine, mouse, rat	2–100 nM (Thorneloe et al., 2012)	Hong et al. (2018), Huh et al. (2012), Marziano et al. (2017), Thorneloe et al. (2012)
HC067047	Mouse, bovine	50–120 nM (Everaerts et al., 2010)	Monaghan et al. (2015), Sonkusare et al. (2014)
RN1734	Rat	2–6 μM (Vincent et al., 2009)	Naik and Walker (2018), Seki et al. (2017)
Ruthenium red	Mouse, rat	<200 nM (Vincent et al., 2009; Watanabe, Davis, et al., 2002)	Kohler et al. (2006), Loot et al. (2008), Sonkusare et al. (2012), Watanabe, Vriens, et al. (2002)