TABLE 4.
Natural products targeting glycolysis in NSCLC.
| No. | Drug name | Target | Publication year | Category | DOI |
|---|---|---|---|---|---|
| 1 | Shikonin | PFKFB/PKM2 pathway | 2022 | Natural compound | 10.1080/21655979.2022.2086378 |
| 2 | Dihydroartemisinin | ERK/c-Myc pathway | 2022 | Natural compound | 10.1016/j.bcp. 2022.114941 |
| 3 | Tanshinone IIA | Sine oculis homeobox homolog 1 (SIX1) | 2022 | Natural compound | 10.3892/ol. 2022.13304 |
| 4 | Ligustilide | PTEN/AKT signaling pathways | 2021 | Natural compound | 10.1016/j.taap. 2020.115336 |
| 5 | α-Hederin | SIRT6 | 2021 | Natural compound | 10.1080/13880209.2020.1862250 |
| 6 | β-Elemene | Adenosine monophosphate-activated protein kinase α (AMPKα) | 2020 | Natural compound | 10.1042/bsr20194389 |
| 7 | Piperlongumine | HK2 | 2019 | Natural compound | 10.7150/ijbs.31749 |
| 8 | Jolkinolide B | HK2/Akt/mTOR pathway | 2018 | Natural compound | 10.1002/jcb.26742 |
| 9 | Triptolide | HK2/Akt/mTOR pathway | 2018 | Natural compound | 10.1016/j.biopha. 2018.04.198 |
| 10 | Deguelin | HK2/AKT1 | 2017 | Natural compound | 10.18632/oncotarget.15937 |
| 11 | Resveratrol | HK2/AKT1 | 2016 | Natural compound | 10.1016/j.yexcr. 2016.11.002 |
| 12 | Oroxylin A | HK2/c-Src | 2013 | Natural compound | 10.1016/j.bbagen. 2013.03.009 |
| 13 | Shenmai injection (SMI) | AKT-mTOR-c-Myc signaling pathway | 2020 | Natural extract | 10.1155/2020/9243681 |
| 14 | Water-extract branch from Cinnamomum cassia Blume | Pyruvate dehydrogenase kinase (PDHK) | 2018 | Natural extract | 10.1016/j.jphs. 2018.10.005 |
| 15 | Hydroalcoholic extract from the leaves of Nerium oleander | Suppression of glycolysis | 2013 | Natural extract | 10.1055/s-0032-1328715 |