Table 2.
Diagnostics of the frontal assessment battery (FAB) in case–control and case-finding scenarios as addressed to HD.
| AUC | Cut-off | J | Se | Sp | PPV | NPV | LR+ | LR– | |
|---|---|---|---|---|---|---|---|---|---|
| HCs vs. HD | |||||||||
| Raw scores | 0.86 | ≤ 15 | 0.56 | 0.68 | 0.88 | 0.74 | 0.84 | 5.6 | 0.36 |
| Adjusted scoresa | 0.88 | < 15.25 | 0.64 | 0.74 | 0.9 | 0.8 | 0.87 | 7.68 | 0.29 |
| HD vs. HD with impaired MoCAb | |||||||||
| Raw scores | 0.9 | ≤ 13 | 0.59 | 0.73 | 0.86 | 0.79 | 0.82 | 5.13 | 0.31 |
| Adjusted scoresa | 0.91 | < 14.35 | 0.71 | 1 | 0.71 | 0.71 | 1 | 3.5 | 0 |
FAB=Frontal Assessment Battery; HCs = healthy controls; HD=Huntington’s disease; MoCA = Montreal Cognitive Assessment; AUC = area under the curve; J = Youden’s index; Se = sensitivity; Sp = specificity; PPV = positive predictive value; NPV = negative predictive value; LR+ =positive likelihood ratio; LR– = negative likelihood ratio.