Table 1.

Univariate Cox regression analyses and other clinicopathologic factors for OS in the entire TCGA set.

Characteristics	Total (N)	Univariate analysis			Multivariate analysis
		HR	95% CI	p-value	HR	95% CI	p-value
Age	477
≤65	194
>65	283	1.610	1.052–2.463	0.028	0.641	0.000–Inf	1
Gender	477
Female	226
Male	251	1.101	0.746–1.625	0.627
T stage	476
T1&T2	94
T3&T4	382	3.072	1.423–6.631	0.004	0.000	0.000–Inf	0.999
N stage	477
N0	283
N1	108	1.681	1.019–2.771	0.042		0.000–Inf	0.999
N2	86	4.051	2.593–6.329	<0.001		0.000–Inf	1
M stage	414
M0	348
M1	66	4.193	2.683–6.554	<0.001	0.003	0.000–Inf	1
Pathologic stage	466
Stage I	81
Stage II	186	2.035	0.785–5.273	0.143		0.000–Inf	0.999
Stage III	133	3.683	1.436–9.448	0.007	0.006	0.000–Inf	1
Stage IV	66	9.294	3.608–23.936	<0.001	1.000	0.000–Inf	1
CEA level	302
≤5	195
>5	107	3.128	1.788–5.471	<0.001	0.000	0.000–Inf	1
Primary therapy outcome	250
PD	25
SD	4	0.930	0.120–7.183	0.944	1.000	1.000–1.000
PR	13	0.271	0.062–1.191	0.084	1.000	1.000–1.000
CR	208	0.087	0.044–0.173	<0.001	0.000	0.000–Inf	0.999
Residual tumor	373
R0	345
R1	4	1.410	0.330–6.014	0.643	1.000	1.000–1.000
R2	24	6.412	3.378–12.172	<0.001	0.001	0.000–Inf	1
Perineural invasion	181
No	135
Yes	46	1.940	0.982–3.832	0.056	1335724.493	0.000–Inf	1
Lymphatic invasion	433
No	265
Yes	168	2.450	1.614–3.720	<0.001	0.840	0.000–Inf	1
History of colon polyps	407
No	262
Yes	145	0.741	0.442–1.242	0.255
Colon polyps present	249
No	162
Yes	87	1.324	0.738–2.373	0.346