Table 3.
Enrichment terms obtained from the KEGG and STRING online tools for each protein set.
| EV vs NT (no. of proteins) | WT vs NT (no. of proteins) | MUT vs NT (no. of proteins) | MUT vs WT (no. of proteins) |
|---|---|---|---|
| Metabolic pathways (7) | Metabolic pathways (15) | Metabolic pathways (12) | Metabolic pathways (5) |
| Alzheimer’s disease (4) | Alzheimer’s disease (7) | Ribosome (8) | Coronavirus disease—COVID-19 (4) |
| Pathways of neurodegeneration—multiple diseases (3) | Amyotrophic lateral sclerosis (7) | Amyotrophic lateral sclerosis (5) | Ribosome (4) |
| Huntington’s disease (3) | Huntington’s disease (7) | Alzheimer’s disease (5) | Alcoholism (3) |
| Oxidative phosphorylation (3) | Parkinson’s disease (6) | Biosynthesis of amino acids (5) | Diabetic cardiomyopathy (3) |
| Parkinson’s disease (3) | Prion disease (6) | Carbon metabolism (5) | Huntington’s disease (3) |
| Alanine, aspartate and glutamate metabolism (4) | Pathways of neurodegeneration— multiple diseases (5) | mRNA Surveillance Pathway (3) | |
| Aminoacyl-tRNA biosynthesis (3) | Salmonella infection (5) | Nucleocytoplasmic transport (3) | |
| Cysteine and methionine metabolism (3) | Diabetic cardiomyopathy (4) | Spliceosome (3) | |
| Carbon metabolism (3) | DNA replication (4) | ||
| Huntington’s disease (4) | |||
| Parkinson’s disease (4) | |||
| Prion disease (4) |
KEGG: https://www.kegg.jp (Kanehisa et al., 2021), STRING: https://string-db.org (Szklarczyk et al., 2019). EV: empty vector transfected cells; NT: non-transfected cells, MUT: mutant transfected cells; and WT: wild-type transfected cells.