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The IC50 values (48 h) of different chemotherapeutic drugs in MCF-7 and MCF-7/Adr cells and the resistance index of MCF-7/Adr cells to each chemotherapeutic drug.
| Drugs | IC50 ± SD (μM),48 h | Resistant index | |
|---|---|---|---|
| MCF-7 | MCF-7/Adr | ||
| DOX | 1.25 ± 0.05 | 350.92 ± 11.10*** | 280.74 |
| HCPT | 9.81 ± 0.11 | 125.28 ± 0.09*** | 12.80 |
| NVT | 4.36 ± 1.11 | 349.80 ± 65.60** | 80.30 |
| EPI | 0.17 ± 0.02 | 4.43 ± 1.01*** | 26.06 |
| VP-16 | 92.85 ± 3.90 | 465.10 ± 8.20*** | 5.00 |
**p<0.01, ***p<0.001, difference versus MCF-7 cells.
