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. 2022 Nov 30;13:1027577. doi: 10.3389/fphar.2022.1027577

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Copyright © 2022 Xu, Sun, Zhang, Dong, Huang, Wang, Jia, Yang, Wang, Jiang, Cao and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Irigenin suppressed the migration of GBM cells. (A) Typical images of DBTRG and C6 cells treated with 50 μM IR for 24 h in wound healing assay. (B–C) Quantification of wound healing index in DBTRG cells (B) and C6 cells (C) as shown in (A) (n = 16, per group). (D) Typical images of DBTRG and C6 cells treated with 50 μM IR for 24 h in transwell invasive assay. (E–F) Quantification of the number of migrated DBTRG (E) (n = 11, per group) and C6 (F) cells (n = 16, per group) as shown in (D). (G–H) qPCR analysis results of MMP-2 mRNA levels (G) and MMP-9 mRNA levels (H) in DBTRG cells treated with or without IR (n = 3, per group). Scale bars, 100 μm. Data were shown as mean ± SEM. ^* p < 0.05, ^*** p < 0.001, compared with control treatment.