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. 2022 Nov 30;9:865788. doi: 10.3389/fmolb.2022.865788

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Copyright © 2022 Li, Han, Zhao, Huang, Feng, Huang, Lan, Huang, Wang, Shen, He, Li, Song, Wang and Meng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Intestinal microbes contribute to PSD depression with metabolic pathways. (A). Evolutionary clade diagram. Group B indicates stroke patients; group C indicates PSD patients. (B). Heatmap depicting the expression of common dysregulated microbes in healthy controls, stroke, and post-stroke depression patients. (C). Paired scatterplot depicting changes in the abundance of common dysregulated microbes in stroke and post-stroke depression patients. (D). Correlation between dysregulated microorganisms and dysregulated metabolites. (E). Global control network depicting differentially expressed genes (hexagons), metabolites (circles), microorganisms (squares), and pathways (diamonds). Note: Group B consists of stroke patients, and group C consists of PSD patients.